PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32061742-7	2020	RESULTS: The medium and high-dose andrographolide (50, 100 mg/kg)group declined the levels of tumor necrosis factor-alpha, interleukin-6 and CXC chemokine ligand2, articular elastase and myeloperoxidase, and increased the levels of antioxidant enzymes superoxide dismutase, catalase, and glutathione.	andrographolide	34-49	tumor necrosis factor	Rattus norvegicus	94-121	
31187188-8	2019	Andrographolide treatment during CCH suppressed astrocyte activation as evidenced by reduced GFAP expression, enhanced expression of BDNF and TrkB, improved impaired spatial learning and memory, and reversed upregulated TNF-alpha, IL-1beta, and caspase-3 expression.	andrographolide	0-15	tumor necrosis factor	Rattus norvegicus	220-229	
31878303-8	2019	Moreover, AND inhibited myeloperoxidase (MPO) activity and the secretion of interleukin-4 (IL-4), IL-13, and tumor necrosis factor alpha (TNF-alpha).	andrographolide	10-13	tumor necrosis factor	Rattus norvegicus	109-136	
31878303-8	2019	Moreover, AND inhibited myeloperoxidase (MPO) activity and the secretion of interleukin-4 (IL-4), IL-13, and tumor necrosis factor alpha (TNF-alpha).	andrographolide	10-13	tumor necrosis factor	Rattus norvegicus	138-147	
29112590-8	2017	ANDRO significantly decreased caveolin-1 and phosphodiesterase delta3 expression, lipopolysaccharide-induced IL-6 and TNF-alpha levels and expression of several chemokine genes, which are associated with reducing inflammation response and decreasing calcium release without affecting normal endothelia cell function, suggesting that ANDRO may be a potential candidate to treat cardiovascular diseases with less toxicity.	andrographolide	0-5	tumor necrosis factor	Rattus norvegicus	118-127	
30820154-7	2019	Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats.	andrographolide	10-25	tumor necrosis factor	Rattus norvegicus	79-106	
28735448-5	2018	The results indicated that andrographolide clearly inhibited the production of NO and TNF-alpha in lipopolysaccharide-activated PMphi in a dose-related manner.	andrographolide	27-42	tumor necrosis factor	Rattus norvegicus	86-95	
35095497-14	2021	The EtOH80 extract (200 mg/kg/day) and andrographolide (30 mg/kg) significantly decreased swelling rate and IL-1alpha, IL-1beta, IL-6, and TNF-alpha in the synovial fluid of rat models in a time-dependent manner, comparable to indomethacin (3 mg/kg/day).	andrographolide	39-54	tumor necrosis factor	Rattus norvegicus	139-148	
29344175-9	2017	Andrographolide decreased NSE, S-100beta, and the inflammation factors, IL-6, IL-1beta and TNF-alpha in serum.	andrographolide	0-15	tumor necrosis factor	Rattus norvegicus	91-100	
25035059-7	2014	Even the lowest tested doses of AP (50 mg/kg/day) or of andrographolide (30 mg/kg/day) suppressed almost maximally the blood IL-1beta and IL-10 as well as brain TNF-alpha and IL-10 expressions induced by chronic stress.	andrographolide	56-71	tumor necrosis factor	Rattus norvegicus	161-170	
21722520-1	2011	AIM: To investigate the effects of andrographolide on the concentration of TNF-alpha and TGF-beta1 in bronchoalveolar lavage fluid (BALF) and the expressions of type I and III collagen mRNA in Lung tissue in bleomycin (BLM)-induced pulmonary fibrosis in rats.	andrographolide	35-50	tumor necrosis factor	Rattus norvegicus	75-84	
21722520-17	2011	Compared with BLM group, the concentration of TGF-beta1 and TNF-alpha in BALF of andrographolide group A had no significant difference.	andrographolide	81-96	tumor necrosis factor	Rattus norvegicus	60-69	
21722520-21	2011	CONCLUSION: In BLM-induced rat pulmonary fibrosis, andrographolide could attenuate alveolitis and fibrosis, decrease mRNA expression of collagen I and III in lung tissue and decrease the concentration of TNF-alpha and TGF-beta1 in BALF.	andrographolide	51-66	tumor necrosis factor	Rattus norvegicus	204-213	
20880404-13	2010	CONCLUSIONS AND IMPLICATIONS: Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-kappaB and microglial activation, and reduction in the production of cytokines including TNF-alpha and IL-1beta, and pro-inflammatory factors such as PGE(2).	andrographolide	30-45	tumor necrosis factor	Rattus norvegicus	206-215	
35095497-13	2021	In the in vitro anti-inflammatory study, EtOH80 extract and andrographolide significantly decreased production of IL-1alpha, IL-1beta, IL-6, and TNF-alpha, as well as inhibited the synthesis of MyD88, NLRP3, NF-kappaB p65, and caspase-1 in a concentration-dependent manner, almost comparable to dexamethasone.	andrographolide	60-75	tumor necrosis factor	Rattus norvegicus	145-154