PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21169355-3	2011	We thus investigated the mechanism involved in andrographolide suppression of NF-kappaB signaling in rat vascular smooth muscle cells (VSMCs) exposed to proinflammatory stimuli, LPS, and IFN-gamma.	andrographolide	47-62	interferon gamma	Rattus norvegicus	187-196	
21169355-4	2011	Andrographolide was shown to suppress LPS/IFN-gamma-induced inducible nitric-oxide synthase and matrix metalloprotease 9 expression in rat VSMCs.	andrographolide	0-15	interferon gamma	Rattus norvegicus	42-51	
21169355-5	2011	Andrographolide also inhibited LPS/IFN-gamma-induced p65 nuclear translocation, DNA binding activity, p65 Ser(536) phosphorylation, and NF-kappaB reporter activity.	andrographolide	0-15	interferon gamma	Rattus norvegicus	35-44	
21169355-9	2011	These results suggest that andrographolide caused neutral sphingomyelinase-mediated ceramide formation and PP2A activation to dephosphorylate p65 Ser(536), leading to NF-kappaB inactivation and subsequent inducible nitric-oxide synthase down-regulation in rat VSMCs stimulated by LPS and IFN-gamma.	andrographolide	27-42	interferon gamma	Rattus norvegicus	288-297