PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24298938-4	2013	We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion.	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	219-237	
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	113-128	C-X-C motif chemokine ligand 8	Homo sapiens	202-206	
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	155-170	C-X-C motif chemokine ligand 8	Homo sapiens	202-206	
32335896-6	2020	In both PBMCs and CSE-exposed U937 cells, andrographolide restored dexamethasone inhibition of IL-8 production, accompanied by the up-regulation of Nrf2 and HDAC2 levels.	andrographolide	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-99	
29672044-0	2018	Andrographolide Antagonizes TNF-alpha-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells.	andrographolide	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	46-50	
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	andrographolide	110-125	C-X-C motif chemokine ligand 8	Homo sapiens	148-152	
29672044-4	2018	However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells.	andrographolide	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	48-52	
29672044-5	2018	The present study was aimed to investigate the effects of andrographolide on TNF-alpha-induced IL-8 expression and its underlying mechanisms.	andrographolide	58-73	C-X-C motif chemokine ligand 8	Homo sapiens	95-99	
29672044-6	2018	We found that andrographolide concentration-dependently inhibited TNF-alpha-induced IL-8 mRNA (2.23 +- 0.15 fold at 20 muM) and protein expression (4.78 +- 0.31 fold at 20 muM) and reduced the IL-8 transcriptional activity (2.59 +- 0.25 fold at 20 muM).	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	84-88	
29672044-6	2018	We found that andrographolide concentration-dependently inhibited TNF-alpha-induced IL-8 mRNA (2.23 +- 0.15 fold at 20 muM) and protein expression (4.78 +- 0.31 fold at 20 muM) and reduced the IL-8 transcriptional activity (2.59 +- 0.25 fold at 20 muM).	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	193-197	
29672044-12	2018	Taken together, andrographolide antagonizes TNF-alpha-induced IL-8 via inhibition of NADPH oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 signaling pathways in HCT116 colorectal cancer cells and then suppresses angiogenesis in the tumor microenvironment.	andrographolide	16-31	C-X-C motif chemokine ligand 8	Homo sapiens	62-66