PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29165873-0	2018	Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1alpha and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells.	andrographolide	0-15	dual specificity phosphatase 10	Homo sapiens	138-143	
29165873-10	2018	Moreover, silencing MKP-5 or treatment with the phosphatase inhibitor vanadate abrogated andrographolide"s suppressing hypoxia-induced p38 MAPK activation and HIF-1alpha expression.	andrographolide	89-104	dual specificity phosphatase 10	Homo sapiens	20-25	
29165873-11	2018	The inhibition of hypoxia-induced HIF-1alpha and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation.	andrographolide	68-83	dual specificity phosphatase 10	Homo sapiens	123-128	
29165873-5	2018	Here, we investigate what role MKP-5 plays in andrographolide"s inhibition of hypoxia-induced expression of HIF-1alpha and ET-1.	andrographolide	46-61	dual specificity phosphatase 10	Homo sapiens	31-36	
29165873-7	2018	Andrographolide enhanced HO-1 and MKP-5 expression and cellular cGMP content in addition to inhibiting hypoxia-induced ROS generation.	andrographolide	0-15	dual specificity phosphatase 10	Homo sapiens	34-39