PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35095497-13	2021	In the in vitro anti-inflammatory study, EtOH80 extract and andrographolide significantly decreased production of IL-1alpha, IL-1beta, IL-6, and TNF-alpha, as well as inhibited the synthesis of MyD88, NLRP3, NF-kappaB p65, and caspase-1 in a concentration-dependent manner, almost comparable to dexamethasone.	andrographolide	60-75	RELA proto-oncogene, NF-kB subunit	Homo sapiens	208-221	
32551381-5	2020	In this study, we observed andrographolide inhibiting activation of NF-kappaB p65 (nuclear factor kappa-light-chain-enhancer of activated B cells) and JNK MAPK (c-Jun N-terminal Kinase Mitogen-Activated Protein Kinase) pathways, however, it did not provide any protective effect against induced stress in the SH-SY5Y cells.	andrographolide	27-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	68-81	
22771630-7	2012	ODQ and KT5823, respective inhibitors of guanylate cyclase and cyclic GMP-dependent kinase (PKG), strongly reversed andrographolide-mediated inhibition of platelet aggregation, relative [Ca(2+)]i mobilization, and IKKbeta, and p65 phosphorylation.	andrographolide	116-131	RELA proto-oncogene, NF-kB subunit	Homo sapiens	227-230	
32066043-9	2020	RELA, a core factor of the NF-kappaB pathway was inhibited by AGP in addition to phosphorylation of AKT and ERK1/2.	andrographolide	62-65	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-4	
24298938-4	2013	We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion.	andrographolide	14-29	RELA proto-oncogene, NF-kB subunit	Homo sapiens	189-192	
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	113-128	RELA proto-oncogene, NF-kB subunit	Homo sapiens	74-77	
22402211-9	2012	Andrographolide treatment also significantly reduced immunoreactivity of COX-2, phosphorylated p50 and p65, and NGF in ectopic endometrium.	andrographolide	0-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	103-106	
19201922-11	2009	In normal human bronchial epithelial cells, andrographolide blocked tumor necrosis factor-alpha-induced phosphorylation of inhibitory kappaB kinase-beta, and downstream inhibitory kappaB alpha degradation, p65 subunit of NF-kappaB phosphorylation, and p65 nuclear translocation and DNA-binding activity.	andrographolide	44-59	RELA proto-oncogene, NF-kB subunit	Homo sapiens	206-230	
19201922-11	2009	In normal human bronchial epithelial cells, andrographolide blocked tumor necrosis factor-alpha-induced phosphorylation of inhibitory kappaB kinase-beta, and downstream inhibitory kappaB alpha degradation, p65 subunit of NF-kappaB phosphorylation, and p65 nuclear translocation and DNA-binding activity.	andrographolide	44-59	RELA proto-oncogene, NF-kB subunit	Homo sapiens	206-209