PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24298938-4	2013	We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion.	andrographolide	14-29	interleukin 6	Homo sapiens	242-246	
29511440-8	2018	Enzyme-linked immunosorbent assay (ELISA), flow cytometry and western blotting analyses showed that andrographolide could decreased the levels of proinflammatory factors TNF-alpha, IL-1beta, IL-6 and IL-17A in the serum and in the colon tissues, reduced the percentages of Th17 cells in CD4+ cells, and suppressed the levels of IL-23, IL-17A, ROR-gammat (key transcription factor of Th17 cells) and p-STAT3 in the colon tissues.	andrographolide	100-115	interleukin 6	Homo sapiens	191-195	
24803294-0	2014	Andrographolide suppresses IL-6/Stat3 signaling in peripheral blood mononuclear cells from patients with chronic rhinosinusitis with nasal polyps.	andrographolide	0-15	interleukin 6	Homo sapiens	27-31	
24803294-6	2014	Andrographolide significantly inhibited IL-6 and IL-17 production, suppressed p-Stat3 expression, and inhibited Th17 differentiation of PBMCs in vitro.	andrographolide	0-15	interleukin 6	Homo sapiens	40-44	
24799081-6	2014	The IC50 value of A. paniculata extract was significantly higher than that of andrographolide on IL-1alpha, IL-1beta, and IL-6 (p < 0.001) release.	andrographolide	78-93	interleukin 6	Homo sapiens	122-126	
24799081-7	2014	The IC50 values of andrographolide for IL-1alpha, IL-1beta, and IL-6 were significantly higher (p < 0.001) than that of dexamethasone.	andrographolide	19-34	interleukin 6	Homo sapiens	64-68	
34163151-8	2021	Results: Three phytocompounds including isoorientin, lupeol, and andrographolide have shown strong interactions with the targeted protein IL-6 with least binding energies (-7.1 to -7.7 kcal/mol).	andrographolide	65-80	interleukin 6	Homo sapiens	138-142	
30218674-6	2018	The levels of TNF-alpha and IL-6 were significantly decreased after treatment with Andro, both in vivo and in vitro, due to the inhibition of nuclear transcription factor-kappaB (NF-kappaB) signaling pathway activation.	andrographolide	83-88	interleukin 6	Homo sapiens	28-32	
28584977-10	2017	AD treatment significantly reduced the production of serum anti-CII, TNFalpha, IL-1beta, and IL-6.	andrographolide	0-2	interleukin 6	Homo sapiens	93-97	
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	113-128	interleukin 6	Homo sapiens	193-197	
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	155-170	interleukin 6	Homo sapiens	193-197	
21442031-0	2010	Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.	andrographolide	0-15	interleukin 6	Homo sapiens	46-59	
21442031-2	2010	Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals.	andrographolide	103-118	interleukin 6	Homo sapiens	68-72	
21442031-2	2010	Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals.	andrographolide	103-118	interleukin 6	Homo sapiens	244-248	
21442031-2	2010	Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals.	andrographolide	103-118	interleukin 6	Homo sapiens	244-248	
21442031-3	2010	Andrographolide inhibits IL-6 expression at both mRNA and protein levels in a dose-dependent manner.	andrographolide	0-15	interleukin 6	Homo sapiens	25-29	
21442031-4	2010	Andrographolide suppresses both IL-6 autocrine loop- and paracrine loop-induced cell signaling including Stat3 and Erk phosphorylation.	andrographolide	0-15	interleukin 6	Homo sapiens	32-36	
21442031-6	2010	Moreover, treatment of andrographolide to mice bearing castration-resistant DU145 human prostate tumors that express constitutive IL-6 autocrine loop significantly suppresses tumor growth.	andrographolide	23-38	interleukin 6	Homo sapiens	130-134	
21442031-7	2010	Taken together, these results demonstrate that andrographolide could be developed as a therapeutic agent to treat both androgen-stimulated and castration-resistant prostate cancer possibly by suppressing IL-6 expression and IL-6-induced signaling.	andrographolide	47-62	interleukin 6	Homo sapiens	204-208	
21442031-7	2010	Taken together, these results demonstrate that andrographolide could be developed as a therapeutic agent to treat both androgen-stimulated and castration-resistant prostate cancer possibly by suppressing IL-6 expression and IL-6-induced signaling.	andrographolide	47-62	interleukin 6	Homo sapiens	224-228	
21779488-5	2011	The authors have previously identified andrographolide as an inhibitor of interleukin-6, which can suppress tumor growth of prostate cancer cells by screening compounds from the Prestwick Natural compound library.	andrographolide	39-54	interleukin 6	Homo sapiens	74-87