PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31862870-9 2019 Taken together, Andrographolide ameliorates RILI by suppressing AIM2 inflammasome mediated-pyroptosis in macrophage, identifying Andrographolide as a novel potential protective agent for RILI. andrographolide 129-144 absent in melanoma 2 Mus musculus 64-68 31862870-0 2019 Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. andrographolide 55-70 absent in melanoma 2 Mus musculus 14-18 31862870-6 2019 Moreover, Andrographolide markedly hampered radiation-induced activation of the AIM2 inflammasome and pyroptosis in vivo. andrographolide 10-25 absent in melanoma 2 Mus musculus 80-84 31862870-7 2019 Furthermore, bone marrow-derived macrophages (BMDMs) were exposed to 8 Gy of X-ray radiation in vitro and Andrographolide significantly inhibited AIM2 inflammasome mediated-pyroptosis in BMDMs. andrographolide 106-121 absent in melanoma 2 Mus musculus 146-150 31862870-8 2019 Mechanistically, Andrographolide effectively prevented AIM2 from translocating into the nucleus to sense DNA damage induced by radiation or chemotherapeutic agents in BMDMs. andrographolide 17-32 absent in melanoma 2 Mus musculus 55-59 31862870-9 2019 Taken together, Andrographolide ameliorates RILI by suppressing AIM2 inflammasome mediated-pyroptosis in macrophage, identifying Andrographolide as a novel potential protective agent for RILI. andrographolide 16-31 absent in melanoma 2 Mus musculus 64-68