PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24998495-0	2014	Andrographolide inhibits TNFalpha-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.	andrographolide	0-15	glutamate-cysteine ligase modifier subunit	Homo sapiens	130-134	
24998495-7	2014	Andrographolide induced the gene expression of heme oxygenase 1 (HO-1) and glutamate cysteine ligase modifier subunit (GCLM) in a time-dependent manner.	andrographolide	0-15	glutamate-cysteine ligase modifier subunit	Homo sapiens	75-117	
24998495-7	2014	Andrographolide induced the gene expression of heme oxygenase 1 (HO-1) and glutamate cysteine ligase modifier subunit (GCLM) in a time-dependent manner.	andrographolide	0-15	glutamate-cysteine ligase modifier subunit	Homo sapiens	119-123	
24998495-11	2014	The mechanism underlying the up-regulation of HO-1 and GCLM by andrographolide was dependent on the PI3K/Akt pathway, and both the Nrf2 and AP-1 transcriptional factors were involved.	andrographolide	63-78	glutamate-cysteine ligase modifier subunit	Homo sapiens	55-59	
24998495-12	2014	Our results suggest that andrographolide attenuates TNFalpha-induced ICAM-1 expression at least partially through suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression, which is PI3K/Akt pathway-dependent.	andrographolide	25-40	glutamate-cysteine ligase modifier subunit	Homo sapiens	180-184	
23146110-12	2013	Andrographolide up-regulated ARE-regulated gene targets including glutamate-cysteine ligase catalytic (GCLC) subunit, GCL modifier (GCLM) subunit, GPx, GR and heme oxygenase-1 in BEAS-2B cells in response to CSE.	andrographolide	0-15	glutamate-cysteine ligase modifier subunit	Homo sapiens	132-136