PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21497192-0	2011	Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-kappaB pathway.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	104-109	
30228000-0	2018	Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	30-35	
30228000-3	2018	We synthesized a series of andrographolide derivatives, and characterized their activity against STAT3 signaling pathway both in vitro and in the CCl4-induced acute liver damage mice model.	andrographolide	27-42	signal transducer and activator of transcription 3	Mus musculus	97-102	
30186451-0	2018	Andrographolide attenuates viral myocarditis through interactions with the IL-10/STAT3 and P13K/AKT/NF-kappabeta signaling pathways.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	81-86	
30186451-6	2018	Effects of andrographolide on the expression of L-10, STAT3, NF-kappabeta p65 and NF-kappabeta p50 were investigated by western blot analysis.	andrographolide	11-26	signal transducer and activator of transcription 3	Mus musculus	54-59	
30186451-7	2018	Results indicated that andrographolide treatment reduced serum levels of TNF-alpha, hs-CRP and cTnl, increased the expression levels of IL-10 and STAT3 and reduced the expression levels of NF-kappabeta p65 and NF-kappabeta p50 and the phosphorylation levels of phosphoinositide 3-kinase (P13K) and AKT in the heart tissues of mice with VMC.	andrographolide	23-38	signal transducer and activator of transcription 3	Mus musculus	146-151	
30186451-9	2018	Therefore, it was concluded that andrographolide may inhibit the progression of VMC by interacting with the IL-10/STAT3 and NF-kappabeta signaling pathways.	andrographolide	33-48	signal transducer and activator of transcription 3	Mus musculus	114-119	
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	andrographolide	10-25	signal transducer and activator of transcription 3	Mus musculus	53-103	
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	andrographolide	10-25	signal transducer and activator of transcription 3	Mus musculus	105-110	
23629921-6	2013	Our data collectively demonstrate that andrographolide confers protection against CS-induced lung inflammation, partially through activation of HO-1 and STAT3.	andrographolide	39-54	signal transducer and activator of transcription 3	Mus musculus	153-158	
23036579-9	2012	Taken together, these results reveal that andrographolide sulfonate ameliorates sepsis in mice through suppressing p38 MAPK, STAT3 and NF-kappaB pathways and suggest that andrographolide sulfonate has an advantage of andrographolide for the treatment of endotoxin shock.	andrographolide	42-57	signal transducer and activator of transcription 3	Mus musculus	125-130	
21497192-8	2011	Western blot analysis showed that andrographolide significantly inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and the protein expression of CCAAT/enhancer-binding protein delta (C/EBPdelta).	andrographolide	34-49	signal transducer and activator of transcription 3	Mus musculus	97-147	
21497192-8	2011	Western blot analysis showed that andrographolide significantly inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and the protein expression of CCAAT/enhancer-binding protein delta (C/EBPdelta).	andrographolide	34-49	signal transducer and activator of transcription 3	Mus musculus	149-154	
21497192-10	2011	Our results demonstrate that andrographolide downregulates inflammatory iNOS and COX-2 gene expression by inhibiting the activation of NF-kappaB and STAT3 by interfering with the expression of SOCS1 and SOCS3 signalling.	andrographolide	29-44	signal transducer and activator of transcription 3	Mus musculus	149-154	
34194525-0	2021	Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	64-69