PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34268377-0	2021	Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway.	andrographolide	0-15	NLR family, pyrin domain containing 3	Rattus norvegicus	45-50	
34268377-6	2021	Andro downregulated the levels of NLRP3, the adaptor molecule apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 in the lungs of BLM-treated rats, suggesting the inhibitory effect of Andro on NLRP3 inflammasome activation in vivo.	andrographolide	211-216	NLR family, pyrin domain containing 3	Rattus norvegicus	34-39	
34268377-6	2021	Andro downregulated the levels of NLRP3, the adaptor molecule apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 in the lungs of BLM-treated rats, suggesting the inhibitory effect of Andro on NLRP3 inflammasome activation in vivo.	andrographolide	211-216	NLR family, pyrin domain containing 3	Rattus norvegicus	220-225	
34268377-8	2021	In vitro, Andro also markedly inhibited BLM-induced NLRP3 inflammasome activation and EMT in A549 cells.	andrographolide	10-15	NLR family, pyrin domain containing 3	Rattus norvegicus	52-57	
34268377-9	2021	Moreover, Andro inhibited BLM-induced phosphorylation of AKT and mTOR in A549 cells, suggesting that AKT/mTOR inactivation mediates Andro-induced effects on BLM-induced NLRP3 inflammasome activation and EMT.	andrographolide	132-137	NLR family, pyrin domain containing 3	Rattus norvegicus	169-174	
35095497-13	2021	In the in vitro anti-inflammatory study, EtOH80 extract and andrographolide significantly decreased production of IL-1alpha, IL-1beta, IL-6, and TNF-alpha, as well as inhibited the synthesis of MyD88, NLRP3, NF-kappaB p65, and caspase-1 in a concentration-dependent manner, almost comparable to dexamethasone.	andrographolide	60-75	NLR family, pyrin domain containing 3	Rattus norvegicus	201-206