PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34944445-11 2021 We demonstrated that ANDRO may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappaB-mediated inflammation. andrographolide 21-26 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 35467270-0 2022 Identification of potential andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening. andrographolide 28-43 NFE2 like bZIP transcription factor 2 Homo sapiens 79-83 35602108-0 2022 URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation. andrographolide 11-26 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 35467270-2 2022 Andrographolide (AGP) regulates the Keap1-Nrf2 pathway by inhibiting the Keap1 protein. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 35467270-2 2022 Andrographolide (AGP) regulates the Keap1-Nrf2 pathway by inhibiting the Keap1 protein. andrographolide 17-20 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 30414976-2 2019 Our earlier studies have demonstrated the ability of andrographolide as well as andrographolide enriched extracts to activate Nrf2/HO-1 pathway through adenosine A2a receptor. andrographolide 53-68 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 32335896-0 2020 Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in COPD. andrographolide 33-48 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 32335896-6 2020 In both PBMCs and CSE-exposed U937 cells, andrographolide restored dexamethasone inhibition of IL-8 production, accompanied by the up-regulation of Nrf2 and HDAC2 levels. andrographolide 42-57 NFE2 like bZIP transcription factor 2 Homo sapiens 148-152 35099120-0 2022 Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 35099120-4 2022 Here, we showed by means of a reporter gene assay that andrographolide exerts its anti-SARS-CoV-2 effects by inhibiting the interaction between Kelch-like ECH-associated protein 1 (KEAP1) and nuclear factor erythroid 2-related factor 2 (NRF2) causing NRF2 upregulation. andrographolide 55-70 NFE2 like bZIP transcription factor 2 Homo sapiens 192-235 35099120-4 2022 Here, we showed by means of a reporter gene assay that andrographolide exerts its anti-SARS-CoV-2 effects by inhibiting the interaction between Kelch-like ECH-associated protein 1 (KEAP1) and nuclear factor erythroid 2-related factor 2 (NRF2) causing NRF2 upregulation. andrographolide 55-70 NFE2 like bZIP transcription factor 2 Homo sapiens 237-241 35099120-4 2022 Here, we showed by means of a reporter gene assay that andrographolide exerts its anti-SARS-CoV-2 effects by inhibiting the interaction between Kelch-like ECH-associated protein 1 (KEAP1) and nuclear factor erythroid 2-related factor 2 (NRF2) causing NRF2 upregulation. andrographolide 55-70 NFE2 like bZIP transcription factor 2 Homo sapiens 251-255 30414976-2 2019 Our earlier studies have demonstrated the ability of andrographolide as well as andrographolide enriched extracts to activate Nrf2/HO-1 pathway through adenosine A2a receptor. andrographolide 80-95 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 30414976-3 2019 Present study investigated ability of andrographolide to regulate Nrf2 induced antioxidant defense systems by miRNAs using HepG2 cells. andrographolide 38-53 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 30414976-4 2019 Andrographolide strongly induced Nrf2 which in turn modulated enzymes of glutathione and thioredoxin antioxidant systems. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 30291937-7 2018 However, in the presence of CSE, andrographolide was able to simultaneously increase LC3B-II level and enhance antioxidant defense by decreasing oxidative stress and increasing total antioxidant capacity, through upregulation of nuclear Nrf2 via the p62-Nrf2 positive feedback loop. andrographolide 33-48 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 30291937-0 2018 Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 30291937-7 2018 However, in the presence of CSE, andrographolide was able to simultaneously increase LC3B-II level and enhance antioxidant defense by decreasing oxidative stress and increasing total antioxidant capacity, through upregulation of nuclear Nrf2 via the p62-Nrf2 positive feedback loop. andrographolide 33-48 NFE2 like bZIP transcription factor 2 Homo sapiens 237-241 30291937-9 2018 Our findings revealed for the first time that andrographolide simultaneously upregulated antioxidant defense through the p62-Nrf2 loop and moderately induced apoptosis through impairment of autophagic flux in CSE-exposed bronchial epithelium. andrographolide 46-61 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 27297870-0 2017 Andrographolide inhibits hypoxia-induced HIF-1alpha-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 27297870-12 2017 Taken together, these results suggest that andrographolide suppresses hypoxia-induced pro-inflammatory ET-1 expression by activating Nrf2/HO-1, inhibiting p38 MAPK signaling, and promoting PHD2/3 expression. andrographolide 43-58 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 30071128-0 2018 Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1-Nrf2-Are signaling pathway. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 27297870-9 2017 Silencing Nrf2 and heme oxygenase 1 (HO-1) reversed the inhibitory effects of andrographolide on hypxoia-induced HIF-1alpha mRNA and protein expression. andrographolide 78-93 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 24998495-0 2014 Andrographolide inhibits TNFalpha-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 167-171 27418236-0 2016 Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 85-90 27418236-6 2016 RESULTS: We clearly show that andrographolide via adenosine A2A receptor signalling leads to activation of p38 MAP kinase, resulting in upregulation of Nrf-2, its translocation to nucleus and activation of HO-1. andrographolide 30-45 NFE2 like bZIP transcription factor 2 Homo sapiens 152-157 27418236-9 2016 CONCLUSIONS: Thus, andrographolide probably by binding to adenosine A2a receptor activates Nrf-2 transcription and also inhibits its exclusion from the nucleus by inactivating GSK-3beta, together resulting in activation of HO-1. andrographolide 19-34 NFE2 like bZIP transcription factor 2 Homo sapiens 91-96 24117426-0 2014 Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111 24117426-9 2014 Andrographolide activated p38 MAPK phosphorylation, which stimulated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated HO-1 expression, and this was found to be associated with its anti-HCV activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 69-112 24117426-9 2014 Andrographolide activated p38 MAPK phosphorylation, which stimulated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated HO-1 expression, and this was found to be associated with its anti-HCV activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 24117426-10 2014 CONCLUSIONS AND IMPLICATIONS: Our results demonstrate that andrographolide has the potential to control HCV replication and suggest that targeting the Nrf2-HO-1 signalling pathway might be a promising strategy for drug development. andrographolide 59-74 NFE2 like bZIP transcription factor 2 Homo sapiens 151-155 23146110-3 2013 Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant transcription factor. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 43-86 23146110-3 2013 Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant transcription factor. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 88-92 23146110-4 2013 As Nrf2 activity is reduced in COPD, we hypothesize that andrographolide may have therapeutic value for COPD. andrographolide 57-72 NFE2 like bZIP transcription factor 2 Homo sapiens 3-7 23146110-11 2013 In BEAS-2B cells, andrographolide markedly increased nuclear Nrf2 accumulation, promoted binding to antioxidant response element (ARE) and total cellular glutathione level in response to CSE. andrographolide 18-33 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 23146110-13 2013 CONCLUSIONS: Andrographolide possesses antioxidative properties against cigarette smoke-induced lung injury probably via augmentation of Nrf2 activity and may have therapeutic potential for treating COPD. andrographolide 13-28 NFE2 like bZIP transcription factor 2 Homo sapiens 137-141 20536138-8 2010 Andrographolide increased the rate of nuclear translocation of nuclear factor erythroid 2-related 2 (Nrf2) and induced antioxidant response element-luciferase reporter activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 63-99 20536138-8 2010 Andrographolide increased the rate of nuclear translocation of nuclear factor erythroid 2-related 2 (Nrf2) and induced antioxidant response element-luciferase reporter activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 20536138-10 2010 These results suggest that stimulation of Nrf2-dependent HO-1 expression is involved in the suppression of TNF-alpha-induced ICAM-1 expression exerted by andrographolide. andrographolide 154-169 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 23146110-0 2013 Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. andrographolide 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 99-103