PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34268377-0	2021	Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway.	andrographolide	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	153-156	
21056613-0	2011	Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes.	andrographolide	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	87-90	
21056613-6	2011	In hepatocytes treated with 40 muM andrographolide, immunoblots showed maximal Akt phosphorylation at 0.5 h and maximal c-jun phosphorylation at 3 h. However, pretreatment with PI3K inhibitors, wortmannin and LY294002, or siPI3K inhibited the andrographolide-induced phosphorylation of c-jun and GSTP protein expression.	andrographolide	35-50	AKT serine/threonine kinase 1	Rattus norvegicus	79-82	
21056613-10	2011	In summary, andrographolide induces GSTP gene expression in rat primary hepatocytes through activation of the PI3K/Akt, phosphorylation of c-jun, nuclear accumulation of AP-1, and subsequent binding to the response element in the gene promoter region.	andrographolide	12-27	AKT serine/threonine kinase 1	Rattus norvegicus	115-118	
20610044-5	2010	The roles of nuclear factor kappa B (NF-kappaB) and Akt in andrographolide-mediated sensitization were examined using reporter assays, electrophoretic mobility shift assays, and Western blotting.	andrographolide	59-74	AKT serine/threonine kinase 1	Rattus norvegicus	52-55	
20610044-9	2010	However, the protein level of activated Akt was significantly reduced by andrographolide.	andrographolide	73-88	AKT serine/threonine kinase 1	Rattus norvegicus	40-43	
20610044-12	2010	Andrographolide-mediated radiosensitization was associated with downregulation of Akt and NF-kappaB activity.	andrographolide	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	82-85	
34268377-9	2021	Moreover, Andro inhibited BLM-induced phosphorylation of AKT and mTOR in A549 cells, suggesting that AKT/mTOR inactivation mediates Andro-induced effects on BLM-induced NLRP3 inflammasome activation and EMT.	andrographolide	132-137	AKT serine/threonine kinase 1	Rattus norvegicus	57-60	
34268377-9	2021	Moreover, Andro inhibited BLM-induced phosphorylation of AKT and mTOR in A549 cells, suggesting that AKT/mTOR inactivation mediates Andro-induced effects on BLM-induced NLRP3 inflammasome activation and EMT.	andrographolide	132-137	AKT serine/threonine kinase 1	Rattus norvegicus	101-104	
32019701-0	2020	Neuroprotective effects of andrographolide on chronic cerebral hypoperfusion-induced hippocampal neuronal damage in rats possibly via PTEN/AKT signaling pathway.	andrographolide	27-42	AKT serine/threonine kinase 1	Rattus norvegicus	139-142	
32019701-10	2020	Our results suggest that the PTEN/AKT pathway may be modulated by andrographolide and the damaging effects of CCH on hippocampus may be ameliorated by andrographolide treatment.	andrographolide	66-81	AKT serine/threonine kinase 1	Rattus norvegicus	34-37	
32019701-10	2020	Our results suggest that the PTEN/AKT pathway may be modulated by andrographolide and the damaging effects of CCH on hippocampus may be ameliorated by andrographolide treatment.	andrographolide	151-166	AKT serine/threonine kinase 1	Rattus norvegicus	34-37	
30820154-0	2019	Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway.	andrographolide	22-37	AKT serine/threonine kinase 1	Rattus norvegicus	103-106	
30820154-8	2019	Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt.	andrographolide	23-38	AKT serine/threonine kinase 1	Rattus norvegicus	89-92	
30820154-9	2019	Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator).	andrographolide	25-40	AKT serine/threonine kinase 1	Rattus norvegicus	165-168	
30820154-10	2019	Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.	andrographolide	18-33	AKT serine/threonine kinase 1	Rattus norvegicus	170-173