PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31190744-0	2019	Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity.	andrographolide	0-15	mechanistic target of rapamycin kinase	Homo sapiens	100-104	
22634579-9	2012	Additionally, andrographolide decreased the activity of PI3K/Akt signaling, as demonstrated by down-regulation of the expression of phos-PI3K, phos-Akt, phos-mTOR and phos-p70s6k in U251 and U87 cells.	andrographolide	14-29	mechanistic target of rapamycin kinase	Homo sapiens	158-162	
32787737-0	2020	Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells.	andrographolide	0-15	mechanistic target of rapamycin kinase	Homo sapiens	106-110	
32787737-7	2020	RESULTS: After andrographolide treatment, the expression of phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway-related proteins, glycolytic activity, and cell survival and invasion rates were decreased in HCT116 cells.	andrographolide	15-30	mechanistic target of rapamycin kinase	Homo sapiens	97-126	
32787737-7	2020	RESULTS: After andrographolide treatment, the expression of phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway-related proteins, glycolytic activity, and cell survival and invasion rates were decreased in HCT116 cells.	andrographolide	15-30	mechanistic target of rapamycin kinase	Homo sapiens	128-132	
32787737-9	2020	CONCLUSION: Andrographolide enhanced radiosensitivity by downregulating glycolysis via inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 cells.	andrographolide	12-27	mechanistic target of rapamycin kinase	Homo sapiens	114-118	
26436418-0	2015	Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.	andrographolide	0-15	mechanistic target of rapamycin kinase	Homo sapiens	117-121	
31190744-12	2019	Conclusion: Our findings indicated that Andro played a neuroprotective role via preserving Akt/mTOR activity and increasing antioxidative status in Bup-treated SH-SY5Y cells.	andrographolide	40-45	mechanistic target of rapamycin kinase	Homo sapiens	95-99	
28412728-9	2017	Finally, Akt phosphorylation and phospho-mTOR levels that are normally suppressed by andrographolide were also expressed at normal levels in the absence of ROS.	andrographolide	85-100	mechanistic target of rapamycin kinase	Homo sapiens	41-45	
27639426-0	2016	Inhibition of autophagy by andrographolide resensitizes cisplatin-resistant non-small cell lung carcinoma cells via activation of the Akt/mTOR pathway.	andrographolide	27-42	mechanistic target of rapamycin kinase	Homo sapiens	138-142	
27639426-6	2016	Andrographolide, a natural diterpenoid, promoted the activation of the Akt/mTOR signaling by downregulating PTEN and suppressed autophagy, which subsequently resensitized the resistant cells to cisplatin-mediated apoptosis.	andrographolide	0-15	mechanistic target of rapamycin kinase	Homo sapiens	75-79