PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35305248-0	2022	Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage.	andrographolide	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	122-126	
35305248-10	2022	Our research suggested that Andro alleviated BBB disruption, neuronal apoptosis, and oxidative stress in SAH, possibly via the Nrf2/HO-1 signaling pathway.	andrographolide	28-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131	
31562575-5	2019	Moreover, mechanism study revealed that the anti-inflammatory activity of andrographolide may be related to the suppression of nuclear translocation of NF-kappaB as well as the activation of Nrf2 and HO-1.	andrographolide	74-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	191-195	
31562575-8	2019	In conclusion, andrographolide protected neurons against inflammation-mediated injury via NF-kappaB inhibition and Nrf2/HO-1 activation and resisted oxidative damage via inhibiting ROS production.	andrographolide	15-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119	
31028905-0	2019	Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: Involvement of Nrf2/AE and TLR/NF-kappaB signaling.	andrographolide	27-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	111-115	
30235892-0	2018	Andrographolide Protects PC12 Cells Against beta-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway.	andrographolide	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	123-127	
26746802-0	2016	Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.	andrographolide	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-107	
26746802-4	2016	We determined that andrographolide modulates the mitogen-activated protein kinase (MAPK)-Nrf2-HO-1 signaling cascade in primary cerebral endothelial cells (CECs) to provide positive protection against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in rats.	andrographolide	19-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93	
26746802-5	2016	In the present study, andrographolide (10 muM) increased HO-1 protein and messenger RNA expressions, Nrf2 phosphorylation, and nuclear translocation in CECs, and these activities were disrupted by a p38 MAPK inhibitor, SB203580, but not by the extracellular signal-regulated kinase inhibitor PD98059 or c-Jun amino-terminal kinase inhibitor SP600125.	andrographolide	22-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105	
26746802-7	2016	Moreover, andrographolide-induced Nrf2 and HO-1 protein expressions were significantly inhibited by Nrf2 small interfering RNA.	andrographolide	10-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38	
26746802-7	2016	Moreover, andrographolide-induced Nrf2 and HO-1 protein expressions were significantly inhibited by Nrf2 small interfering RNA.	andrographolide	10-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104	
26746802-11	2016	In conclusion, andrographolide increased Nrf2-HO-1 expression through p38 MAPK regulation, confirming that it provides protection against MCAO-induced brain injury.	andrographolide	15-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	41-45	
25110055-8	2014	Immunoblot analysis and EMSA revealed that andrographolide increased nuclear Nrf2 contents and Nrf2 binding to DNA, respectively.	andrographolide	43-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81	
25110055-8	2014	Immunoblot analysis and EMSA revealed that andrographolide increased nuclear Nrf2 contents and Nrf2 binding to DNA, respectively.	andrographolide	43-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	95-99	
33632062-0	2021	Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells.	andrographolide	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105	
33632062-2	2021	OBJECTIVE: The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium maltolate (Al(mal)3)-induced neurotoxicity in PC12 cell was explored.	andrographolide	27-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	128-132	
33632062-7	2021	Furthermore, Nrf2 and p62 nuclear translocation were increased and keap1 in the cytoplasm was decreased in the presence of Andro.	andrographolide	123-128	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17	
33632062-9	2021	DISCUSSION AND CONCLUSIONS: Our results suggested that Andro could be a promising therapeutic lead against Al-induced neurotoxicity by regulating p62-mediated keap1-Nrf2 pathways.	andrographolide	55-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	165-169