PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33632062-0 2021 Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells. andrographolide 0-15 Kelch-like ECH-associated protein 1 Rattus norvegicus 95-100 33632062-2 2021 OBJECTIVE: The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium maltolate (Al(mal)3)-induced neurotoxicity in PC12 cell was explored. andrographolide 27-32 Kelch-like ECH-associated protein 1 Rattus norvegicus 85-90 33632062-7 2021 Furthermore, Nrf2 and p62 nuclear translocation were increased and keap1 in the cytoplasm was decreased in the presence of Andro. andrographolide 123-128 Kelch-like ECH-associated protein 1 Rattus norvegicus 67-72 33632062-9 2021 DISCUSSION AND CONCLUSIONS: Our results suggested that Andro could be a promising therapeutic lead against Al-induced neurotoxicity by regulating p62-mediated keap1-Nrf2 pathways. andrographolide 55-60 Kelch-like ECH-associated protein 1 Rattus norvegicus 159-164