PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27084510-13	2016	Bax and Apaf-1 expression were notably increased with decreased Bcl-2 and Bcl-xL expression in andrographolide-treated cells.	andrographolide	95-110	BCL2 apoptosis regulator	Homo sapiens	64-69	
17918040-3	2007	Further study showed that Andro induced activation of mitogen-activated protein kinases (MAPKs) including p38 kinase, c-Jun N-terminal kinase (JNK) and extracellular signal-related kinases (ERK1/2), but had no significant effect on caspase-3, Bcl-xL and Bcl-2, which are apoptosis-related proteins.	andrographolide	26-31	BCL2 apoptosis regulator	Homo sapiens	254-259	
25059546-10	2016	Andrographolide caused a dose-dependent increase in Cleaved-Caspase3/Bax protein expression and a decrease in Bcl-2/NF-kappab expression.	andrographolide	0-15	BCL2 apoptosis regulator	Homo sapiens	110-115	
24563380-6	2014	The addition of Andro to CDDP induced synergistic apoptosis, which could be corroborated to the changes in protein and mRNA levels of Bax and Bcl-2, and the increased Fas/FasL association in these cells, resulting in increased release of cytochrome c, and activation of caspases.	andrographolide	16-21	BCL2 apoptosis regulator	Homo sapiens	142-147	
24112174-8	2013	CONCLUSIONS: Andrographolide inhibits BGC-823 cell growth and induces BGC-823 cell apoptosis by up-regulating Bax and caspase-3 expressions and down-regulating Bcl-2 expression.	andrographolide	13-28	BCL2 apoptosis regulator	Homo sapiens	160-165	
22012578-8	2012	Moreover, andrographolide-treated RAFLSs displayed a significant decrease in the Bcl-2/Bax ratio compared to untreated cells.	andrographolide	10-25	BCL2 apoptosis regulator	Homo sapiens	81-86	
21704149-4	2011	Notably, cell death induced by both curcumin and andrographolide was associated with decreased NFkappaB activity and a reduction in Bcl-2 and Bcl-xL expression.	andrographolide	49-64	BCL2 apoptosis regulator	Homo sapiens	132-137	
31306153-10	2019	Taken together, these results indicate that andrographolide, along with carboplatin, synergistically inhibited cell proliferation and induced mitochondrial apoptosis of Hep-2 cells by increasing the intracellular ROS, regulating the mitogen-activated protein kinase and phosphatidylinositol 3-kinase (PI3K/AKT) pathways, altering the BCL2/BAX ratio, and ultimately activating the cleavage of Caspase-3 and PARP.	andrographolide	44-59	BCL2 apoptosis regulator	Homo sapiens	334-338	
16395645-5	2005	An increase of G (0)/G (1) phase cells from 51.88 % to 78.69 % was noted after andrographolide treatment for 36 h. The G (0)/G (1) phase arrest and apoptosis were associated with disappearance of mitochondrial cytochrome c and increased expression of Bax but decreased expression of Bcl-2 proteins in the inhibited cells.	andrographolide	79-94	BCL2 apoptosis regulator	Homo sapiens	283-288	
32679024-13	2021	Flow cytometric evaluation showed andrographolide enhanced early and late apoptotic cells and induced upregulation of proapoptotic (Bax and Bad) and downregulation of antiapoptotic Bcl2 in treated SW-480 cells.	andrographolide	34-49	BCL2 apoptosis regulator	Homo sapiens	181-185	
16740251-0	2006	Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.	andrographolide	55-70	BCL2 apoptosis regulator	Homo sapiens	31-36	
34697748-10	2021	Andrographolide inhibited the colony formation abilities in SGC7901 in a p53-dependent manner followed by induction of mitochondrial intrinsic apoptosis through activation of caspases-9 and -3, cleavage of PARP, and inhibition of pro-apoptotic Bcl-2.	andrographolide	0-15	BCL2 apoptosis regulator	Homo sapiens	244-249	
32046125-9	2020	Cell-migration and expressions of NHE1, V-ATPase, PARP (poly-ADP-ribose-polymerase), pro-Caspase-3, and Bcl-2 were significantly reduced by pretreating with Andrographolide (>=100 muM) for 24-48 h in HeLa.	andrographolide	157-172	BCL2 apoptosis regulator	Homo sapiens	104-109