PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25869056-5	2015	RESULTS: It was found that andrographolide decreased melanin content, TYR activity and transcriptional and protein expression of TYR family and microphthalmia-associated transcription factor (MITF) in B16F10 melanoma cells.	andrographolide	27-42	tyrosinase	Mus musculus	70-73	
25869056-5	2015	RESULTS: It was found that andrographolide decreased melanin content, TYR activity and transcriptional and protein expression of TYR family and microphthalmia-associated transcription factor (MITF) in B16F10 melanoma cells.	andrographolide	27-42	tyrosinase	Mus musculus	129-132	
25869056-6	2015	Data showed andrographolide also decreased melanin content and TYR content in ultraviolet B (UVB) irradiation induced brown guinea pigs.	andrographolide	12-27	tyrosinase	Mus musculus	63-66	
25869056-7	2015	Moreover, we found that melanin content and TYR activity were effectively inhibited in Human Epidermis Melanocyte (HEM) treated with andrographolide at the medium concentrations without apparent effect on cell viability.	andrographolide	133-148	tyrosinase	Mus musculus	44-47	
25869056-11	2015	CONCLUSION: These results demonstrate that andrographolide can effectively suppress melanin content and TYR activity in B16F10 cells, HEM cells and UVB-induced brown guinea pig skin by decreasing phosphorylation of GSK3beta dependent on Akt, promoting the degradation of beta-catenin, inhibiting beta-catenin into the nucleus and decreasing the expression of MITF and TYR family.	andrographolide	43-58	tyrosinase	Mus musculus	104-107	
25869056-11	2015	CONCLUSION: These results demonstrate that andrographolide can effectively suppress melanin content and TYR activity in B16F10 cells, HEM cells and UVB-induced brown guinea pig skin by decreasing phosphorylation of GSK3beta dependent on Akt, promoting the degradation of beta-catenin, inhibiting beta-catenin into the nucleus and decreasing the expression of MITF and TYR family.	andrographolide	43-58	tyrosinase	Mus musculus	368-371