PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29146293-3	2017	Real time PCR, Western bloting, flow cytometric and immunofluorescence studies demonstrated that andrographolide inhibited lipopolysaccharide (LPS)-induced overexpression of HMGB1, TLR4, NFkappaB, COX-2, iNOS, and release of inflammatory mediators in primary mix glial culture, adult mice prefrontal cortex and hippocampus region.	andrographolide	97-112	toll-like receptor 4	Mus musculus	181-185	
10780958-3	2000	RAW 264.7 cells stimulated with LPS/IFN-gamma activated NO production; in this condition andrographolide (1-100 microM) inhibited NO production in a dose-dependent manner with an IC(50) value of 17.4+/-1.1 microM.	andrographolide	89-104	toll-like receptor 4	Mus musculus	32-35	
29743985-0	2018	Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-kappaB and TGF-beta1/Smad2 Signaling Pathways.	andrographolide	0-15	toll-like receptor 4	Mus musculus	67-71	
24719558-0	2014	Andrographolide suppress tumor growth by inhibiting TLR4/NF-kappaB signaling activation in insulinoma.	andrographolide	0-15	toll-like receptor 4	Mus musculus	52-56	
27183596-4	2016	The present study investigated whether andrographolide could restore steroid sensitivity to block LPS/IFN-gamma-induced IL-27 production and AHR via its antioxidative property.	andrographolide	39-54	toll-like receptor 4	Mus musculus	98-101	
27183596-8	2016	Andrographolide significantly restored the suppressive effect of dexamethasone on LPS/IFN-gamma-induced IL-27 mRNA and protein levels in the macrophage cell line and primary lung monocytes/macrophages, mouse bronchoalveolar lavage fluid and lung tissues, and AHR in mice.	andrographolide	0-15	toll-like receptor 4	Mus musculus	82-85	
27183596-11	2016	Andrographolide significantly restored nuclear HDAC2 protein levels and total HDAC activity, and it diminished the total histone acetyltransferase/HDAC activity ratio in mouse lungs exposed to LPS/IFN-gamma, possibly via suppression of PI3K/Akt/HDAC2 phosphorylation, and upregulation of the antioxidant transcription factor NF erythroid-2-related factor 2 level and DNA binding activity.	andrographolide	0-15	toll-like receptor 4	Mus musculus	193-196