PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33592561-2 2021 Ten years after the publication of the phase III, randomized, ABC-02 trial, the combination of cisplatin plus gemcitabine remains the standard first-line treatment for patients with advanced BTC. gemcitabine 110-121 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 62-65 32705228-0 2020 Low-intensity low-frequency ultrasound enhances the chemosensitivity of gemcitabine-resistant ASPC-1 cells via PI3K/AKT/NF-kappaB pathway-mediated ABC transporters. gemcitabine 72-83 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 147-150 32705228-13 2020 The expression levels of ABC transporters, PI3K-P110alpha and NF-kappaB were decreased in the GEM+LILFU group. gemcitabine 94-97 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 25-28 28366930-0 2017 Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells. gemcitabine 0-11 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 55-58 28366930-0 2017 Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells. gemcitabine 62-73 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 55-58 28366930-0 2017 Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells. gemcitabine 62-73 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 55-58 28366930-6 2017 RESULTS We synthesized Abc-GC-gemcitabine nanoparticles successfully with the encapsulation rate of nanobioconjugates was 91.63% and the drug loadings was 9.97%. gemcitabine 30-41 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 23-26 28366930-8 2017 Moreover, Abc-GC-gemcitabine microspheres expressed more significant inhibited action than GC-gemcitabine microspheres efficiently CONCLUSIONS Our data suggested that Abc-GC-gemcitabine nanoparticles could have promising potential in treating metastasized and chemoresistant pancreatic cancer by enhancing the drug efficacy and minimizing off target effects. gemcitabine 17-28 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 10-13 28366930-8 2017 Moreover, Abc-GC-gemcitabine microspheres expressed more significant inhibited action than GC-gemcitabine microspheres efficiently CONCLUSIONS Our data suggested that Abc-GC-gemcitabine nanoparticles could have promising potential in treating metastasized and chemoresistant pancreatic cancer by enhancing the drug efficacy and minimizing off target effects. gemcitabine 17-28 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 167-170 34123574-7 2021 Gemcitabine or cisplatin-resistant cell lines show an increased proportion of CD44+/CD24+/EpCAM+ cancer stem like cells as well as an increased number of ABC transporter ABCG2 positive cells compared to the parental cell lines. gemcitabine 0-11 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 154-157 28366930-8 2017 Moreover, Abc-GC-gemcitabine microspheres expressed more significant inhibited action than GC-gemcitabine microspheres efficiently CONCLUSIONS Our data suggested that Abc-GC-gemcitabine nanoparticles could have promising potential in treating metastasized and chemoresistant pancreatic cancer by enhancing the drug efficacy and minimizing off target effects. gemcitabine 94-105 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 167-170 35538494-0 2022 Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer. gemcitabine 92-103 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 64-67 35538494-2 2022 Various factors, such as ATP binding cassette (ABC) transporters, microRNAs and their downstream signaling pathways are included in chemoresistance to gemcitabine. gemcitabine 151-162 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 47-50 35538494-3 2022 This study investigated the potential mechanisms of microRNAs and ABC transporters related signaling pathways for PC resistance to gemcitabine both in vivo and in vitro. gemcitabine 131-142 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 66-69 35538494-5 2022 Molecular docking analysis was performed to explore whether gemcitabine interacted with ABC transporters. gemcitabine 60-71 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 88-91 35538494-9 2022 Molecular docking analysis revealed that gemcitabine can bind to the ABC transporters. gemcitabine 41-52 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 69-72 35538494-16 2022 Interestingly, hsa-miR-3178 promoted gemcitabine resistance in PC by activating the PI3K/Akt pathway-mediated upregulation of ABC transporters. gemcitabine 37-48 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 126-129 35538494-17 2022 CONCLUSIONS: Our results indicate that hsa-miR-3178 promotes gemcitabine resistance via RhoB/PI3K/Akt signaling pathway-mediated upregulation of ABC transporters. gemcitabine 61-72 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 145-148