PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23320839-11 2013 Treatment of gemcitabine or doxorubicin activated phosphorylated ERK and induced the upregulation of MRP1 and MRP3. gemcitabine 13-24 ATP binding cassette subfamily C member 1 Homo sapiens 101-105 31546820-5 2019 We observed increased gemcitabine chemoresistance, with an almost nine-fold higher EC50 as compared to a monolayer culture (31 nM versus 277 nM), and an alleviated expression and function of the multidrug resistance protein (MRP) family. gemcitabine 22-33 ATP binding cassette subfamily C member 1 Homo sapiens 195-223 31546820-5 2019 We observed increased gemcitabine chemoresistance, with an almost nine-fold higher EC50 as compared to a monolayer culture (31 nM versus 277 nM), and an alleviated expression and function of the multidrug resistance protein (MRP) family. gemcitabine 22-33 ATP binding cassette subfamily C member 1 Homo sapiens 225-228 31115606-10 2019 Finally, knockdown of GHET1 also inhibited the expression of ABCC1 protein in Gemcitabine-resistant BC cells. gemcitabine 78-89 ATP binding cassette subfamily C member 1 Homo sapiens 61-66 31115606-11 2019 CONCLUSIONS: High expression of GHET1 was related with the low sensitivity to Gemcitabine of BC; GHET1 contributed to chemotherapeutic resistance to Gemcitabine in BC through up-regulating ABCC1 expression. gemcitabine 78-89 ATP binding cassette subfamily C member 1 Homo sapiens 189-194 31115606-11 2019 CONCLUSIONS: High expression of GHET1 was related with the low sensitivity to Gemcitabine of BC; GHET1 contributed to chemotherapeutic resistance to Gemcitabine in BC through up-regulating ABCC1 expression. gemcitabine 149-160 ATP binding cassette subfamily C member 1 Homo sapiens 189-194 23664167-12 2013 CONCLUSION: Loss of RUNX3 expression contributes to gemcitabine resistance by inducing MRP expression, thereby resulting in poor patient survival. gemcitabine 52-63 ATP binding cassette subfamily C member 1 Homo sapiens 87-90 23320839-12 2013 MEK inhibitors U0126 and AZD6244 deactivated phosphorylated ERK, decreased endogenous MRP1 expression, reversed gemcitabine or doxorubicin induced MRP1 and MRP3 upregulation, and increased the intracellular doxorubicin accumulation. gemcitabine 112-123 ATP binding cassette subfamily C member 1 Homo sapiens 147-151 29552197-4 2018 It was revealed that, with elevation of initial gemcitabine concentration, expression of ABCB1, ABCC and ABCG2 mRNA and corresponding downstream proteins was increased while promoter methylation was decreased. gemcitabine 48-59 ATP binding cassette subfamily C member 1 Homo sapiens 96-100 25564970-0 2015 Time and concentration dependency of P-gp, MRP1 and MRP5 induction in response to gemcitabine uptake in Capan-2 pancreatic cancer cells. gemcitabine 82-93 ATP binding cassette subfamily C member 1 Homo sapiens 43-47 25564970-4 2015 The present study investigated the time course and dose dependency of the induction of three efflux proteins, P-gp, MRP1 and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels. gemcitabine 146-157 ATP binding cassette subfamily C member 1 Homo sapiens 116-120 25564970-8 2015 The estimated Km and Vmax confirmed that MRP5 and to a lesser extent MRP1 are the prominent proteins for efflux of gemcitabine. gemcitabine 115-126 ATP binding cassette subfamily C member 1 Homo sapiens 69-73 23392708-7 2013 Furthermore, Western blotting revealed that LY294002 combined with gemcitabine reduced the protein levels of p-Akt and MRP, which contributed to the inhibition of proliferation. gemcitabine 67-78 ATP binding cassette subfamily C member 1 Homo sapiens 119-122 12799644-5 2003 The doxorubicin-resistant cells 2R120 (MRP1) and 2R160 (P-gP) were nine- and 28-fold more sensitive to gemcitabine than their parental SW1573 cells, respectively (P<0.01), which was completely reverted by 25 micro M verapamil. gemcitabine 103-114 ATP binding cassette subfamily C member 1 Homo sapiens 39-43 21804948-10 2011 In summary, ABCC-mediated efflux may contribute to gemcitabine resistance through increased dFdU efflux that allows for the continuation of gemcitabine deamination. gemcitabine 51-62 ATP binding cassette subfamily C member 1 Homo sapiens 12-16 21804948-10 2011 In summary, ABCC-mediated efflux may contribute to gemcitabine resistance through increased dFdU efflux that allows for the continuation of gemcitabine deamination. gemcitabine 140-151 ATP binding cassette subfamily C member 1 Homo sapiens 12-16 12799644-10 2003 P-glycoprotein and MRP1 overexpression possibly caused a cellular stress resulting in increased gemcitabine metabolism and sensitivity, while reversal of collateral gemcitabine sensitivity by verapamil also suggests a direct relation between the presence of membrane efflux pumps and gemcitabine sensitivity. gemcitabine 96-107 ATP binding cassette subfamily C member 1 Homo sapiens 19-23 33002234-6 2021 RESULTS: Prior to gemcitabine exposure, MRP1, 2, 4, 5 and 6 mRNA were expressed in HuCCT1 cells and MRP1, 3, 4 and 5 in KMBC cells. gemcitabine 18-29 ATP binding cassette subfamily C member 1 Homo sapiens 40-59 35538494-8 2022 RESULTS: We found that P-gp, BCRP and MRP1 were highly expressed in gemcitabine-resistant PC tissues and cells. gemcitabine 68-79 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 9598134-0 1998 Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines. gemcitabine 25-36 ATP binding cassette subfamily C member 1 Homo sapiens 49-52