PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35602350-0 2022 The Levels of TNF-alpha, Tissue Factor, and Coagulation Function in Rats with Pulmonary Hypertension and the Intervention Effect of Sildenafil Encapsulated by Targeted Nanocarriers. Sildenafil Citrate 132-142 tumor necrosis factor Rattus norvegicus 14-23 35602350-10 2022 Compared with the NS group, the pulmonary small blood vessel media thickness, myocardial cell area, and the levels of TNF-alpha and TF in the TNC-sildenafil group were reduced (P < 0.05). Sildenafil Citrate 146-156 tumor necrosis factor Rattus norvegicus 118-127 35602350-11 2022 Targeting nanocarrier encapsulation of sildenafil can obviously reduce the average pulmonary artery pressure in rats with pulmonary hypertension, improve pulmonary vascular media proliferation and myocardial hypertrophy, and restore the levels of TNF-alpha, TF, and CF to a normal state. Sildenafil Citrate 39-49 tumor necrosis factor Rattus norvegicus 247-256 33865881-8 2021 Sildenafil showed the best protection regarding TNF-alpha and NF-kappaB, while cilostazol showed the best results regarding TLR4, HMGB1 and histopathological examination. Sildenafil Citrate 0-10 tumor necrosis factor Rattus norvegicus 48-57 23499693-7 2013 Additionally, immunohistochemical analysis demonstrated that sildenafil treatment markedly reduced inducible nitric oxide synthase, tumor necrosis factor-alpha, and caspase-3 expressions, while expression of endothelial nitric oxide synthase was prominently enhanced. Sildenafil Citrate 61-71 tumor necrosis factor Rattus norvegicus 132-159 26377490-6 2015 CONCLUSION: The renoprotective effect of sildenafil against renal I/R might be due to the activation of antioxidant genes (Nrf2, HO-1 and NQO-1) and antiapoptotic gene (Bcl2) and attenuation of proinflammatory cytokines (TNF-a, IL-1beta and ICAM-1). Sildenafil Citrate 41-51 tumor necrosis factor Rattus norvegicus 221-226 31009843-9 2019 RESULTS: Pre-treatment with sildenafil (1 and 3 mg/kg ip) and tadalafil (1 and 3 mg/kg ip) significantly reduced the levels of pro-inflammatory cytokines IL-4 and TNF-alpha in rat serum and BALF. Sildenafil Citrate 28-38 tumor necrosis factor Rattus norvegicus 163-172 29623781-4 2018 Methods We reported that the PC12 cells pre-treatment with sildenafil (0.008 muM) for 60 min and then exposing the cells to HG (25 mM for 72 h) or normal glucose (NG) (5 mM for 72 h) condition, show: Results (1) significant attenuation in reactive oxygen species, MDA and TNF-a levels, Bax/Bcl-2 ratio, expression of caspase 3 and UCP2 proteins; (2) significant increase in viability, GSH/GSSG ratio, mitochondrial membrane potential, and ATP levels. Sildenafil Citrate 59-69 tumor necrosis factor Rattus norvegicus 272-277 26511444-13 2015 Sildenafil treatment normalizes IL-1beta and TNF-alpha levels, p38 phosphorylation, and membrane expression of GABAA, AMPA, and NMDA receptors and restores spatial learning. Sildenafil Citrate 0-10 tumor necrosis factor Rattus norvegicus 45-54 25277360-9 2015 RESULTS: Sildenafil reduced TNF-alpha tissue levels and increased body weight. Sildenafil Citrate 9-19 tumor necrosis factor Rattus norvegicus 28-37 25277360-11 2015 The combined treatment with sildenafil and U-74389G reduced tissue levels of both TNF-alpha and MDA, lowered CMDI and microscopic Geboes score, and increased body weight. Sildenafil Citrate 28-38 tumor necrosis factor Rattus norvegicus 82-91 25277360-13 2015 We confirmed that sildenafil has anti-inflammatory capacity by reducing colonic TNF-alpha and by improving body weight. Sildenafil Citrate 18-28 tumor necrosis factor Rattus norvegicus 80-89 23953793-7 2013 Compared with the saline + I/R group, sildenafil + I/R group had significant decreases in Bax, p53, Bax/Bcl-2 ratio, caspase 3, IL-6, TNF-alpha level, and W/D weight ratio but an increase in Bcl-2 expression (P < 0.05). Sildenafil Citrate 38-48 tumor necrosis factor Rattus norvegicus 134-143 23953793-8 2013 Compared with the sildenafil + sham group, there were significant increases in p53 and TNF-alpha expression in the sildenafil + I/R group (P < 0.05). Sildenafil Citrate 115-125 tumor necrosis factor Rattus norvegicus 87-96 22059996-12 2011 Sildenafil treatment decreased the serum tumour necrosis factor (TNF)-alpha level when compared to the CLP group. Sildenafil Citrate 0-10 tumor necrosis factor Rattus norvegicus 41-75 22059996-13 2011 Our results indicate that sildenafil is a highly protective agent in preventing lung and kidney damage caused by CLP-induced sepsis via maintenance of the oxidant-anti-oxidant status and decrease in the level of TNF-alpha. Sildenafil Citrate 26-36 tumor necrosis factor Rattus norvegicus 212-221