PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27171763-8	2016	Our results suggest that caution may be warranted when CYP-related co-medications are administered during sildenafil treatment for PH.	Sildenafil Citrate	106-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	55-58	
11298070-0	2001	Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.	Sildenafil Citrate	81-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-37	
11298070-1	2001	AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism.	Sildenafil Citrate	95-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41	
11298070-1	2001	AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism.	Sildenafil Citrate	95-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46	
11298070-1	2001	AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism.	Sildenafil Citrate	193-203	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46	
11298070-1	2001	AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism.	Sildenafil Citrate	193-203	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46	
11298070-5	2001	RESULTS: Sildenafil conversion was found to be mediated by at least two CYP enzymes, for which the mean kinetic parameters were Km1 = 6(+/-3 microM), Km2 = 81(+/-45 microM), Vmax1 = 22(+/-9 pmol) and Vmax2 = 138(+/-77 pmol) UK-103 320 formed min(-1) mg(-1).	Sildenafil Citrate	9-19	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-75