PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25736380-3 2015 Treatment of cells with OSU-03012/sildenafil: abolished the expression of multiple oncogenic growth factor receptors and plasma membrane drug efflux pumps and caused a rapid degradation of GRP78 and other HSP70 and HSP90 family chaperone proteins. Sildenafil Citrate 34-44 heat shock protein family A (Hsp70) member 5 Homo sapiens 189-194 27903966-4 2017 [Pemetrexed + sildenafil] reduced the expression of c-FLIP-s, MCL-1 and BCL-XL that was blocked in a cell-type -dependent fashion by either over-expression of HSP90 / GRP78 / HSP70 / HSP27 or by blockade of eIF2alpha-CHOP signaling. Sildenafil Citrate 14-24 heat shock protein family A (Hsp70) member 5 Homo sapiens 167-172 26887051-7 2016 AR-12 combined with sildenafil in a GRP78 plus HSP27 -dependent fashion to profoundly activate an eIF2alpha/ATF4/CHOP/Beclin1 pathway in parallel with inactivating mTOR and increasing ATG13 phosphorylation, collectively resulting in formation of punctate toxic autophagosomes. Sildenafil Citrate 20-30 heat shock protein family A (Hsp70) member 5 Homo sapiens 36-41 25858032-2 2015 Sorafenib/regorafenib and the multi-kinase inhibitor pazopanib (Votrient) interacted with sildenafil (Viagra) to further rapidly reduce GRP78 levels in eukaryotes and as single agents to reduce Dna K levels in prokaryotes. Sildenafil Citrate 90-100 heat shock protein family A (Hsp70) member 5 Homo sapiens 136-141 25858032-2 2015 Sorafenib/regorafenib and the multi-kinase inhibitor pazopanib (Votrient) interacted with sildenafil (Viagra) to further rapidly reduce GRP78 levels in eukaryotes and as single agents to reduce Dna K levels in prokaryotes. Sildenafil Citrate 102-108 heat shock protein family A (Hsp70) member 5 Homo sapiens 136-141 25546329-2 2015 The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Sildenafil Citrate 54-64 heat shock protein family A (Hsp70) member 5 Homo sapiens 4-9 25546329-2 2015 The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Sildenafil Citrate 54-64 heat shock protein family A (Hsp70) member 5 Homo sapiens 114-119 25546329-2 2015 The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Sildenafil Citrate 66-72 heat shock protein family A (Hsp70) member 5 Homo sapiens 4-9 25546329-2 2015 The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Sildenafil Citrate 66-72 heat shock protein family A (Hsp70) member 5 Homo sapiens 114-119