PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33741394-0 2021 Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications. Sildenafil Citrate 0-10 protein kinase cGMP-dependent 1 Homo sapiens 78-81 33588236-3 2021 Here, we show that phosphodiesterase-5 inhibitors, sildenafil and tadalafil, promote IFN-gamma and IL-4 production in iNKT cells in a cGMP-PKG pathway dependent manner. Sildenafil Citrate 51-61 protein kinase cGMP-dependent 1 Homo sapiens 139-142 31253872-6 2019 Neratinib interacted with the PKG activator sildenafil and the HMG CoA reductase inhibitor atorvastatin to further reduce K-RAS expression, and to further enhance cell killing. Sildenafil Citrate 44-54 protein kinase cGMP-dependent 1 Homo sapiens 30-33 31654676-8 2020 Intriguingly, we found that the oocyte maturation could be stimulated by treatment of either two different PDE5a inhibitors, sildenafil or tadalafil, and such effects could be completely blocked by a PKG inhibitor KT5823 and two gap junction blockers, respectively. Sildenafil Citrate 125-135 protein kinase cGMP-dependent 1 Homo sapiens 200-203 32231130-11 2020 Sildenafil, a inhibitor of the PDE5A-cGMP-PKG pathway, preserved the mitochondrial structure, respiratory chain efficiency and energy status in cardiac tissue. Sildenafil Citrate 0-10 protein kinase cGMP-dependent 1 Homo sapiens 42-45 26971999-7 2016 Collectively, our data identify this cGMP-cGKI pathway as the link between sildenafil usage and increased melanoma risk. Sildenafil Citrate 75-85 protein kinase cGMP-dependent 1 Homo sapiens 42-46 26269433-12 2015 These results provide novel mechanistic insights into the action of cGMP-PKG-related antihypertrophic agents, such as NO donors and sildenafil. Sildenafil Citrate 132-142 protein kinase cGMP-dependent 1 Homo sapiens 73-76 19961855-1 2010 Increased cyclic GMP from enhanced synthesis or suppressed catabolism (e.g. PDE5 inhibition by sildenafil, SIL) activates protein kinase G (PKG) and blunts cardiac pathological hypertrophy. Sildenafil Citrate 95-105 protein kinase cGMP-dependent 1 Homo sapiens 122-138 22285803-12 2012 Phosphodiestaerase-5 (PDE-5 inhibitor) sildenafil augmented ANP-mediated effects on hnRNPA1 phosphorylation, translocation to nucleus and nuclear cGK activity. Sildenafil Citrate 39-49 protein kinase cGMP-dependent 1 Homo sapiens 146-149 21851826-9 2011 We further found that pretreatment of cells with sildenafil suppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs. Sildenafil Citrate 49-59 protein kinase cGMP-dependent 1 Homo sapiens 256-272 21851826-9 2011 We further found that pretreatment of cells with sildenafil suppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs. Sildenafil Citrate 49-59 protein kinase cGMP-dependent 1 Homo sapiens 274-277 21851826-10 2011 SIGNIFICANCE: Our study suggests that enhanced PKG activity suppresses calcineurin/NFATc2 cascade-mediated cyclin A expression, CDK2 activation and PASMC proliferation to contribute to the overall effects of sildenafil in the treatment of pulmonary hypertension. Sildenafil Citrate 208-218 protein kinase cGMP-dependent 1 Homo sapiens 47-50 19961855-1 2010 Increased cyclic GMP from enhanced synthesis or suppressed catabolism (e.g. PDE5 inhibition by sildenafil, SIL) activates protein kinase G (PKG) and blunts cardiac pathological hypertrophy. Sildenafil Citrate 95-105 protein kinase cGMP-dependent 1 Homo sapiens 140-143 16469645-9 2006 CONCLUSIONS: The current results demonstrate a potent relaxant effect of sildenafil in penile resistance arteries due in part to cGMP accumulation and to the enhanced effects of basal released, endothelial derived NO acting through PKG activation. Sildenafil Citrate 73-83 protein kinase cGMP-dependent 1 Homo sapiens 232-235 19416631-6 2009 The inhibitive effects of sildenafil, however, were fully reversed by concomitant presence of PKG inhibitor in cells. Sildenafil Citrate 26-36 protein kinase cGMP-dependent 1 Homo sapiens 94-97 19416631-8 2009 Meanwhile, these two pathways are also separately modulated by enhanced cGMP-PKG signalling derived from inhibition of PDE5 with sildenafil to confer the overall roles of sildenafil against pulmonary hypertension. Sildenafil Citrate 129-139 protein kinase cGMP-dependent 1 Homo sapiens 77-80 19416631-8 2009 Meanwhile, these two pathways are also separately modulated by enhanced cGMP-PKG signalling derived from inhibition of PDE5 with sildenafil to confer the overall roles of sildenafil against pulmonary hypertension. Sildenafil Citrate 171-181 protein kinase cGMP-dependent 1 Homo sapiens 77-80 15739122-7 2005 On the other hand, treatment of PASMC with inhibitors of cGMP-dependent protein kinase (PKG) or cAMP-dependent protein kinase (PKA) reversed the antiproliferative effect of sildenafil. Sildenafil Citrate 173-183 protein kinase cGMP-dependent 1 Homo sapiens 88-91 15840396-5 2005 Results suggest that sildenafil produces its local peripheral antinociceptive effect via activation of the cyclic GMP-PKG-K+ channel pathway. Sildenafil Citrate 21-31 protein kinase cGMP-dependent 1 Homo sapiens 118-121 15739122-9 2005 This effect was partially reduced by PKG inhibition and completely abolished by PKA inhibition.We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK. Sildenafil Citrate 112-122 protein kinase cGMP-dependent 1 Homo sapiens 37-40 15739122-9 2005 This effect was partially reduced by PKG inhibition and completely abolished by PKA inhibition.We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK. Sildenafil Citrate 112-122 protein kinase cGMP-dependent 1 Homo sapiens 225-228 15333581-6 2004 The NO donor diethylamine NONOate (DEANO), the PKG activator 8-pCPT-cGMP, and the PDE-5 inhibitor sildenafil, cause dose-dependent clitoral relaxation that is inhibited by antagonists of PKG (Rp-8-Br-cGMPS) or BK(Ca) channels (iberiotoxin). Sildenafil Citrate 98-108 protein kinase cGMP-dependent 1 Homo sapiens 187-190