PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25823699-8 2015 Emerging therapies include the osmotic agent mannitol (Bronchitol), the intracellular Ca(2+)-raising agent Moli1901/lancovutide, the CFTR potentiator sildenafil [phosphodiesterase type 5 (PDE5) inhibitor] and the CFTR "corrector" VX-809 (lumacaftor). Sildenafil Citrate 150-160 CF transmembrane conductance regulator Homo sapiens 133-137 15618584-0 2005 Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis. Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 39-43 22698459-7 2012 Preclinical data with inhibitors of phosphodiesterase type 5, such as sildenafil and analogs, have highlighted their potential for CFTR pharmacotherapy. Sildenafil Citrate 70-80 CF transmembrane conductance regulator Homo sapiens 131-135 22613978-0 2012 Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease. Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 48-52 22613978-2 2012 In the context of cystic fibrosis (CF), a genetic disease caused by a defective CFTR gene (e.g. DeltaF508-CFTR), it was assumed that sildenafil could be a promising substance to correct impaired protein expression. Sildenafil Citrate 133-143 CF transmembrane conductance regulator Homo sapiens 80-84 22613978-2 2012 In the context of cystic fibrosis (CF), a genetic disease caused by a defective CFTR gene (e.g. DeltaF508-CFTR), it was assumed that sildenafil could be a promising substance to correct impaired protein expression. Sildenafil Citrate 133-143 CF transmembrane conductance regulator Homo sapiens 106-110 22613978-3 2012 This study focuses on the molecular mechanisms of sildenafil on CFTR recovery. Sildenafil Citrate 50-60 CF transmembrane conductance regulator Homo sapiens 64-68 22613978-6 2012 Sildenafil increased I(m), G(m), and C(m) of wt-CFTR and functionally restored DeltaF508-CFTR in oocytes. Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 48-52 22613978-6 2012 Sildenafil increased I(m), G(m), and C(m) of wt-CFTR and functionally restored DeltaF508-CFTR in oocytes. Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 89-93 22613978-8 2012 Transepithelial measurements revealed that sildenafil mediated increase (wt-CFTR) and restoration (DeltaF508-CFTR) of channel activity. Sildenafil Citrate 43-53 CF transmembrane conductance regulator Homo sapiens 76-80 22613978-8 2012 Transepithelial measurements revealed that sildenafil mediated increase (wt-CFTR) and restoration (DeltaF508-CFTR) of channel activity. Sildenafil Citrate 43-53 CF transmembrane conductance regulator Homo sapiens 109-113 22613978-10 2012 From these data we conclude that sildenafil mediates potentiation of CFTR activity by a cGMP-dependent and initiates cGMP-independent functional insertion of CFTR/DeltaF508-CFTR molecules into the apical membranes. Sildenafil Citrate 33-43 CF transmembrane conductance regulator Homo sapiens 69-73 22613978-10 2012 From these data we conclude that sildenafil mediates potentiation of CFTR activity by a cGMP-dependent and initiates cGMP-independent functional insertion of CFTR/DeltaF508-CFTR molecules into the apical membranes. Sildenafil Citrate 33-43 CF transmembrane conductance regulator Homo sapiens 158-162 22613978-10 2012 From these data we conclude that sildenafil mediates potentiation of CFTR activity by a cGMP-dependent and initiates cGMP-independent functional insertion of CFTR/DeltaF508-CFTR molecules into the apical membranes. Sildenafil Citrate 33-43 CF transmembrane conductance regulator Homo sapiens 158-162 22613978-11 2012 Thus, sildenafil is a corrector and potentiator of CFTR/DeltaF508-CFTR. Sildenafil Citrate 6-16 CF transmembrane conductance regulator Homo sapiens 51-55 22613978-11 2012 Thus, sildenafil is a corrector and potentiator of CFTR/DeltaF508-CFTR. Sildenafil Citrate 6-16 CF transmembrane conductance regulator Homo sapiens 66-70 15618584-0 2005 Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis. Sildenafil Citrate 12-18 CF transmembrane conductance regulator Homo sapiens 39-43 15618584-4 2005 CFTR location was determined using immunofluorescence and confocal imaging in untreated cells and cells treated with sildenafil. Sildenafil Citrate 117-127 CF transmembrane conductance regulator Homo sapiens 0-4 15618584-5 2005 The effect of sildenafil treatment on CFTR chloride transport function was measured in CF15 cells using an iodide efflux assay. Sildenafil Citrate 14-24 CF transmembrane conductance regulator Homo sapiens 38-42 15618584-7 2005 Exposure of cells to sildenafil (2 hours at 37 degrees C) resulted in recruitment of DeltaF508-CFTR to the apical membrane and the appearance of chloride transport activity. Sildenafil Citrate 21-31 CF transmembrane conductance regulator Homo sapiens 95-99 15618584-8 2005 Sildenafil also increased DeltaF508-CFTR trafficking in cells from individuals with CF with a single copy DeltaF508 (DeltaF508/4016ins) or with a newly described CF trafficking mutation (R1283M). Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 36-40 15618584-9 2005 CONCLUSIONS: The findings provide proof of principle for sildenafil as a DeltaF508-CFTR trafficking drug and give encouragement for future testing of sildenafil and related PDE5 inhibitors in patients with CF. Sildenafil Citrate 57-67 CF transmembrane conductance regulator Homo sapiens 83-87 30168731-2 2018 Sildenafil, a phosphodiesterase type 5 inhibitor, not only enhances nitric oxide (NO) metabolism but has been shown to improve CFTR functionality as well. Sildenafil Citrate 0-10 CF transmembrane conductance regulator Homo sapiens 127-131