PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23415811-9 2013 Sildenafil also increased MEF2 phosphorylation and Bcl-2/Bax and Bcl-xL/Bax ratios, effects that might as well contribute to prevent cell death. Sildenafil Citrate 0-10 BCL2 associated X, apoptosis regulator Rattus norvegicus 57-60 23953793-7 2013 Compared with the saline + I/R group, sildenafil + I/R group had significant decreases in Bax, p53, Bax/Bcl-2 ratio, caspase 3, IL-6, TNF-alpha level, and W/D weight ratio but an increase in Bcl-2 expression (P < 0.05). Sildenafil Citrate 38-48 BCL2 associated X, apoptosis regulator Rattus norvegicus 90-93 23953793-7 2013 Compared with the saline + I/R group, sildenafil + I/R group had significant decreases in Bax, p53, Bax/Bcl-2 ratio, caspase 3, IL-6, TNF-alpha level, and W/D weight ratio but an increase in Bcl-2 expression (P < 0.05). Sildenafil Citrate 38-48 BCL2 associated X, apoptosis regulator Rattus norvegicus 100-103 23415811-9 2013 Sildenafil also increased MEF2 phosphorylation and Bcl-2/Bax and Bcl-xL/Bax ratios, effects that might as well contribute to prevent cell death. Sildenafil Citrate 0-10 BCL2 associated X, apoptosis regulator Rattus norvegicus 72-75 23171857-11 2012 Further, sildenafil treatment attenuated glomerulosclerosis and tubulointerstitial fibrosis in DSH rats and counteracted the increased expression of ED-1, TGF-beta1, and Bax and the decreased expression of Bcl-2 in the kidneys of these rats. Sildenafil Citrate 9-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 170-173 20574430-4 2010 Diabetic rats on sildenafil or tadalafil showed significant increased cavernous Bcl(2) and decreased Bax with upgraded Bcl(2)/Bax ratio that was improved being on T. Diabetic rats on alternate sildenafil/tadalafil with or without T showed further significant increased cavernous tissue Bcl(2) with upgraded Bcl(2)/Bax ratio. Sildenafil Citrate 17-27 BCL2 associated X, apoptosis regulator Rattus norvegicus 101-104 20574430-4 2010 Diabetic rats on sildenafil or tadalafil showed significant increased cavernous Bcl(2) and decreased Bax with upgraded Bcl(2)/Bax ratio that was improved being on T. Diabetic rats on alternate sildenafil/tadalafil with or without T showed further significant increased cavernous tissue Bcl(2) with upgraded Bcl(2)/Bax ratio. Sildenafil Citrate 17-27 BCL2 associated X, apoptosis regulator Rattus norvegicus 126-129 20574430-4 2010 Diabetic rats on sildenafil or tadalafil showed significant increased cavernous Bcl(2) and decreased Bax with upgraded Bcl(2)/Bax ratio that was improved being on T. Diabetic rats on alternate sildenafil/tadalafil with or without T showed further significant increased cavernous tissue Bcl(2) with upgraded Bcl(2)/Bax ratio. Sildenafil Citrate 17-27 BCL2 associated X, apoptosis regulator Rattus norvegicus 126-129 19474186-12 2009 In conclusion, this study suggests that sildenafil has antiapoptotic effects in experimental IR renal injury via ERK phosphorylation, induction of iNOS and eNOS production, and a decrease in the Bax/Bcl-2 ratio. Sildenafil Citrate 40-50 BCL2 associated X, apoptosis regulator Rattus norvegicus 195-198 19474186-9 2009 Pretreatment with sildenafil in IR rats increased ERK phosphorylation and reduced the renal Bax/Bcl-2 ratio, renal caspase-3 activity, and terminal dUTP nick end-labeling-positive apoptotic cells. Sildenafil Citrate 18-28 BCL2 associated X, apoptosis regulator Rattus norvegicus 92-95 19152827-7 2009 Renal Bax gene and protein expression was significantly higher in cisplatin-treated rats compared with control rats, and sildenafil treatment significantly reduced the levels of Bax and increased the renal Bax/Bcl-2 ratio (P<0.05). Sildenafil Citrate 121-131 BCL2 associated X, apoptosis regulator Rattus norvegicus 178-181 19152827-7 2009 Renal Bax gene and protein expression was significantly higher in cisplatin-treated rats compared with control rats, and sildenafil treatment significantly reduced the levels of Bax and increased the renal Bax/Bcl-2 ratio (P<0.05). Sildenafil Citrate 121-131 BCL2 associated X, apoptosis regulator Rattus norvegicus 178-181 34530523-7 2021 The I/R group had significantly higher JNK, p38 MAPK, Bax, caspase-3, and NF-kappaB levels, and lower ERK and Bcl-2 levels in the bladder than the sham-operated group; these changes were significantly ameliorated by metformin and/or sildenafil treatment. Sildenafil Citrate 233-243 BCL2 associated X, apoptosis regulator Rattus norvegicus 54-57 29623781-4 2018 Methods We reported that the PC12 cells pre-treatment with sildenafil (0.008 muM) for 60 min and then exposing the cells to HG (25 mM for 72 h) or normal glucose (NG) (5 mM for 72 h) condition, show: Results (1) significant attenuation in reactive oxygen species, MDA and TNF-a levels, Bax/Bcl-2 ratio, expression of caspase 3 and UCP2 proteins; (2) significant increase in viability, GSH/GSSG ratio, mitochondrial membrane potential, and ATP levels. Sildenafil Citrate 59-69 BCL2 associated X, apoptosis regulator Rattus norvegicus 286-289