PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17585066-6 2007 Sildenafil increased tissue cGMP levels independently of increases in nitric oxide production, and sildenafil therapy stimulated angiogenesis in ischemic limbs of eNOS-/- and iNOS-/- mice. Sildenafil Citrate 99-109 nitric oxide synthase 2, inducible Mus musculus 175-179 16951048-2 2007 Previous studies have suggested that the protective effects of sildenafil are mediated via activation of endothelial nitric oxide (NO) synthesis (eNOS) and inducible NOS (iNOS). Sildenafil Citrate 63-73 nitric oxide synthase 2, inducible Mus musculus 156-169 16951048-2 2007 Previous studies have suggested that the protective effects of sildenafil are mediated via activation of endothelial nitric oxide (NO) synthesis (eNOS) and inducible NOS (iNOS). Sildenafil Citrate 63-73 nitric oxide synthase 2, inducible Mus musculus 171-175 16951048-4 2007 Treatment with 0.06 mg/kg sildenafil 5 min before reperfusion significantly reduced myocardial infarct size in wild-type, eNOS null mice (eNOS(-/-)), and iNOS(-/-) animals. Sildenafil Citrate 26-36 nitric oxide synthase 2, inducible Mus musculus 154-158 16951048-6 2007 These results suggest that acute low-dose sildenafil-mediated cardioprotection is independent of eNOS, iNOS, and cGMP. Sildenafil Citrate 42-52 nitric oxide synthase 2, inducible Mus musculus 103-107 32302594-4 2020 The aim of the present study was to investigate the potential role of OXT receptors and their downstream calcineurin (CN)/inducible nitric oxide synthase (iNOS) pathways in proconvulsant effects of sildenafil. Sildenafil Citrate 198-208 nitric oxide synthase 2, inducible Mus musculus 122-153 12637371-6 2003 Reverse transcription-polymerase chain reaction revealed a transient increase in endothelial and inducible NO synthase (eNOS and iNOS, respectively) mRNA in sildenafil-treated mice, peaking at 45 minutes (eNOS) and 2 hours (iNOS) after sildenafil injection. Sildenafil Citrate 157-167 nitric oxide synthase 2, inducible Mus musculus 97-118 12637371-6 2003 Reverse transcription-polymerase chain reaction revealed a transient increase in endothelial and inducible NO synthase (eNOS and iNOS, respectively) mRNA in sildenafil-treated mice, peaking at 45 minutes (eNOS) and 2 hours (iNOS) after sildenafil injection. Sildenafil Citrate 157-167 nitric oxide synthase 2, inducible Mus musculus 129-133 12637371-6 2003 Reverse transcription-polymerase chain reaction revealed a transient increase in endothelial and inducible NO synthase (eNOS and iNOS, respectively) mRNA in sildenafil-treated mice, peaking at 45 minutes (eNOS) and 2 hours (iNOS) after sildenafil injection. Sildenafil Citrate 157-167 nitric oxide synthase 2, inducible Mus musculus 224-228 12637371-8 2003 In addition, a significant increase in both iNOS and eNOS protein was detected 24 hours after sildenafil treatment. Sildenafil Citrate 94-104 nitric oxide synthase 2, inducible Mus musculus 44-48 12637371-9 2003 A selective inhibitor of iNOS, 1400W (10 mg/kg IP given 30 minutes before I-R), abolished sildenafil-induced protection (23.7+/-2.8%, P<0.05 versus sildenafil). Sildenafil Citrate 90-100 nitric oxide synthase 2, inducible Mus musculus 25-29 12637371-9 2003 A selective inhibitor of iNOS, 1400W (10 mg/kg IP given 30 minutes before I-R), abolished sildenafil-induced protection (23.7+/-2.8%, P<0.05 versus sildenafil). Sildenafil Citrate 151-161 nitric oxide synthase 2, inducible Mus musculus 25-29 15668244-11 2005 Sildenafil-induced protection against necrosis and apoptosis was absent in the myocytes derived from iNOS knock-out mice and was attenuated in eNOS knock-out myocytes. Sildenafil Citrate 0-10 nitric oxide synthase 2, inducible Mus musculus 101-105 32302594-12 2020 Collectively, our data provide insights into the role of OXT receptor/CN/iNOS pathway in the proconvulsant aspect of sildenafil. Sildenafil Citrate 117-127 nitric oxide synthase 2, inducible Mus musculus 73-77 32302594-4 2020 The aim of the present study was to investigate the potential role of OXT receptors and their downstream calcineurin (CN)/inducible nitric oxide synthase (iNOS) pathways in proconvulsant effects of sildenafil. Sildenafil Citrate 198-208 nitric oxide synthase 2, inducible Mus musculus 155-159 23970812-9 2013 Sildenafil has at least a partial anti-inflammatory effect through iNOS inhibition, as its effect on iNOS(-/-) mice was limited. Sildenafil Citrate 0-10 nitric oxide synthase 2, inducible Mus musculus 67-71 29807031-8 2018 Individual treatment with sildenafil or selenium showed partial neuroprotection, simultaneously with lower hippocampal expression of 4-hydroneonenal (4-HNE), nitrotyrosine, iNOS and HO-1, yet without reaching normal levels. Sildenafil Citrate 26-36 nitric oxide synthase 2, inducible Mus musculus 173-177 29807031-10 2018 The joint treatment with sildenafil and selenium preserved hippocampal neuronal count, improved kindling score, blunted lipid peroxides and nitrotyrosine levels, concomitantly with iNOS inhibition, normalization of TrxR activity and HO-1 expression, and evident neo-angiogenesis. Sildenafil Citrate 25-35 nitric oxide synthase 2, inducible Mus musculus 181-185 31004733-10 2019 Repeated sildenafil treatment also increased the hippocampal expression of iNOS and nNOS isoforms, while the blockade of muscarinic receptors attenuated both sildenafil-induced proconvulsant effect and brain nitrite changes. Sildenafil Citrate 9-19 nitric oxide synthase 2, inducible Mus musculus 75-79 28468928-6 2017 Polyps in sildenafil treated mice were also less inflamed; they exhibited reduced myeloid-cell infiltration and reduced expression of iNOS, IFNgamma, and IL6 compared with untreated controls. Sildenafil Citrate 10-20 nitric oxide synthase 2, inducible Mus musculus 134-138 26404052-14 2015 In addition, the administration of sildenafil reduced expression of GFAP, NFkB, inactive AMPK and iNOS, and increased IKbetaalpha. Sildenafil Citrate 35-45 nitric oxide synthase 2, inducible Mus musculus 98-102 24727400-14 2014 The treatment of iNOS(-/-) animals with sildenafil resulted in an increase of all proteins (pro-inflammatory effect). Sildenafil Citrate 40-50 nitric oxide synthase 2, inducible Mus musculus 17-21 24727400-17 2014 Sildenafil increased GSTpi and resulted in an improved myelin structure in iNOS(-/-) mice. Sildenafil Citrate 0-10 nitric oxide synthase 2, inducible Mus musculus 75-79 23970812-0 2013 Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS/NO system in an inflammatory demyelination model. Sildenafil Citrate 0-10 nitric oxide synthase 2, inducible Mus musculus 73-77 23970812-9 2013 Sildenafil has at least a partial anti-inflammatory effect through iNOS inhibition, as its effect on iNOS(-/-) mice was limited. Sildenafil Citrate 0-10 nitric oxide synthase 2, inducible Mus musculus 101-105 19286961-2 2009 We further hypothesized that PKG-dependent activation of survival kinase ERK may play a causative role in sildenafil-induced cardioprotection via induction of endothelial nitric oxide synthase (eNOS)/inducible nitric oxide synthase (iNOS) and Bcl-2. Sildenafil Citrate 106-116 nitric oxide synthase 2, inducible Mus musculus 200-231 19286961-2 2009 We further hypothesized that PKG-dependent activation of survival kinase ERK may play a causative role in sildenafil-induced cardioprotection via induction of endothelial nitric oxide synthase (eNOS)/inducible nitric oxide synthase (iNOS) and Bcl-2. Sildenafil Citrate 106-116 nitric oxide synthase 2, inducible Mus musculus 233-237 19286961-9 2009 Western blots revealed that sildenafil significantly increased phosphorylation of ERK1/2 and GSK-3beta and induced iNOS, eNOS, Bcl-2, and PKG activity in the heart 24 h after treatment. Sildenafil Citrate 28-38 nitric oxide synthase 2, inducible Mus musculus 115-119 19286961-12 2009 We conclude that these studies provide first direct evidence that PKG-dependent ERK phosphorylation is indispensable for the induction of eNOS/iNOS and Bcl-2 and the resulting cardioprotection by sildenafil. Sildenafil Citrate 196-206 nitric oxide synthase 2, inducible Mus musculus 143-147