PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25042931-3 2014 In mice lacking dystrophin, restoration of nNOS effects by a phosphodiesterase 5 (PDE5) inhibitor (sildenafil) improves skeletal and cardiac muscle performance. Sildenafil Citrate 99-109 nitric oxide synthase 1, neuronal Mus musculus 43-47 15668244-9 2005 The increase of Bcl-2 expression by sildenafil was inhibited by nitric-oxide synthase (NOS) inhibitor, L-nitro-amino-methyl-ester. Sildenafil Citrate 36-46 nitric oxide synthase 1, neuronal Mus musculus 64-85 18456872-0 2008 Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil. Sildenafil Citrate 128-138 nitric oxide synthase 1, neuronal Mus musculus 56-77 22145776-12 2012 CONCLUSIONS: Irrespective of the hormonal status, sildenafil decreased leak point pressure by a nNOS-mediated mechanism. Sildenafil Citrate 50-60 nitric oxide synthase 1, neuronal Mus musculus 96-100 16425058-1 2006 RATIONALE: Sildenafil citrate is widely prescribed for erectile dysfunction and acts by inhibiting phosphodiesterase type-5, resulting in accumulation of cyclic-guanosine monophosphate (cGMP) via activation of nitric oxide synthase (NOS). Sildenafil Citrate 11-29 nitric oxide synthase 1, neuronal Mus musculus 210-231 12086978-18 2002 These data reveal the relative importance of nNOS, compared to eNOS, as the critical NOS isoform in the control of erectile function and illustrate that the nNOS isoform is required for sildenafil-induced facilitation of erectile responses in vivo in mice. Sildenafil Citrate 186-196 nitric oxide synthase 1, neuronal Mus musculus 45-49 12086978-18 2002 These data reveal the relative importance of nNOS, compared to eNOS, as the critical NOS isoform in the control of erectile function and illustrate that the nNOS isoform is required for sildenafil-induced facilitation of erectile responses in vivo in mice. Sildenafil Citrate 186-196 nitric oxide synthase 1, neuronal Mus musculus 157-161 33290345-6 2021 The antidepressant-like effect of carbamazepine (40 mg/kg, intraperitoneal) was prevented by pretreatment with L-arginine [substrate for NO synthase (NOS), 750 mg/kg, intraperitoneal], sildenafil (a PDE-5 inhibitor, 5 mg/kg, intraperitoneal) and diazoxide (K channels opener, 10 mg/kg). Sildenafil Citrate 185-195 nitric oxide synthase 1, neuronal Mus musculus 137-148