PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29660387-5	2018	In 12 month-old rats, a long-term treatment with sildenafil (PDE5 inhibitor) normalized testosterone/nitrite levels in circulation and cGMP accumulation in TIF; improved Leydig cell steroidogenic capacity; decreased MEK, ERK1/2 and PRKG1 expression; prevented an increase in the Leydig cells number and atrophy of seminiferous tubules leading to histological appearance of young rat testes.	Sildenafil Citrate	49-59	mitogen activated protein kinase 3	Rattus norvegicus	221-227	
21325817-13	2011	CONCLUSIONS: 1) Reperfusion injury would result from ROS-triggered MAPK-mediated NHE-1 phosphorylation (and reactivation) during reperfusion; 2) sildenafil protects the myocardium by favouring NHE-1 dephosphorylation and bypassing ROS generation.	Sildenafil Citrate	145-155	mitogen activated protein kinase 3	Rattus norvegicus	67-71	
25133539-5	2014	Furthermore, sildenafil reduced extracellular signal-regulated kinase (ERK)1/2 and p38 MAPK activation while enhanced activation of the cytoprotective Akt pathway in PH.	Sildenafil Citrate	13-23	mitogen activated protein kinase 3	Rattus norvegicus	32-78	
23140764-9	2012	In the subacute LVH group, both KMUP-1 and sildenafil administered for 10 days attenuated the LVH in SHRs, with enhanced eNOS/cGMP/PKG and suppressed iNOS/calcineurin A/ERK1/2 expression in the left ventricle.	Sildenafil Citrate	43-53	mitogen activated protein kinase 3	Rattus norvegicus	169-175	
21948520-6	2012	Sildenafil promoted ERK1/2 activation an effect that was paralleled by an increase in MnSOD expression that persisted 24 hr later.	Sildenafil Citrate	0-10	mitogen activated protein kinase 3	Rattus norvegicus	20-26	
17898384-9	2007	Sildenafil inhibition of ERK1/2 was accompanied by a rapid induction of MKP-1.	Sildenafil Citrate	0-10	mitogen activated protein kinase 3	Rattus norvegicus	25-31	
17898384-0	2007	The antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylation.	Sildenafil Citrate	32-42	mitogen activated protein kinase 3	Rattus norvegicus	181-220	
17898384-8	2007	Sildenafil (96 microM) also caused a 67% decrease in PDGF-stimulated ERK1/2 phosphorylation.	Sildenafil Citrate	0-10	mitogen activated protein kinase 3	Rattus norvegicus	69-75	
17898384-11	2007	Either vanadate (12.5 microM), a phosphatase inhibitor, or Rp-8-BrcGMPS abolished the inhibitory effect of sildenafil on PDGF-stimulated phosphorylation of ERK1/2 and restored PDGF-induced cell proliferation.	Sildenafil Citrate	107-117	mitogen activated protein kinase 3	Rattus norvegicus	156-162	
17898384-12	2007	CONCLUSION: This study indicates that sildenafil upregulates MKP-1 expression and promotes degradation of phosphorylation of ERK1/2, which suppresses the proliferation of pulmonary artery smooth muscle cells.	Sildenafil Citrate	38-48	mitogen activated protein kinase 3	Rattus norvegicus	125-131