PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30546426-11 2018 Markedly decreased Akt phosphorylation and cyclin D1 levels and increased p53 levels were detected when cells were transfected with miR-128 mimics. mir-128 132-139 tumor protein p53 Homo sapiens 74-77 30546426-14 2018 In conclusion, the results suggested that miR-128 was a specific negative regulator of RPN2, which regulated colorectal cancer cell proliferation and migration by affecting the Akt-p53-cyclin pathway. mir-128 42-49 tumor protein p53 Homo sapiens 181-184 23492773-0 2013 miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis. mir-128 0-7 tumor protein p53 Homo sapiens 41-44 26553132-5 2015 It promoted the association of p53 to the promoter region of miR-128, and enhanced the transcriptional activation of p53 on miR-128 expression. mir-128 61-68 tumor protein p53 Homo sapiens 31-34 23492773-10 2013 Pretreatment with PUMA and Bak siRNAs abolished miR-128-induced apoptosis in HCT116 p53+/+ and HCT116 p53-/- cells. mir-128 48-55 tumor protein p53 Homo sapiens 84-87 23492773-4 2013 We herein demonstrate that miR-128 positively regulates p53 activity. mir-128 27-34 tumor protein p53 Homo sapiens 56-59 23492773-10 2013 Pretreatment with PUMA and Bak siRNAs abolished miR-128-induced apoptosis in HCT116 p53+/+ and HCT116 p53-/- cells. mir-128 48-55 tumor protein p53 Homo sapiens 102-105 23492773-6 2013 miR-128 inhibition of SIRT1 led to an increase in acetylated p53 and its transcriptional targets. mir-128 0-7 tumor protein p53 Homo sapiens 61-64 23492773-11 2013 Taken together, we present the first evidence of miR-128 to be a new component joining the p53 network. mir-128 49-56 tumor protein p53 Homo sapiens 91-94 23492773-12 2013 This study emphasizes that miR-128 is a novel mitochondria-targeted miRNA that can be further evaluated as a chemotherapeutic agent for human cancers as it induces apoptosis irrespective of p53 status. mir-128 27-34 tumor protein p53 Homo sapiens 190-193 23492773-8 2013 We further demonstrated that miR-128 augments the antitumor effect of compounds that target the p53 pathway. mir-128 29-36 tumor protein p53 Homo sapiens 96-99 23492773-9 2013 Furthermore, miR-128 induces apoptosis in wild (WT) p53 as well as in mutant p53-expressing cells in a p53-dependent and -independent manner via induction of PUMA. mir-128 13-20 tumor protein p53 Homo sapiens 52-55 23492773-9 2013 Furthermore, miR-128 induces apoptosis in wild (WT) p53 as well as in mutant p53-expressing cells in a p53-dependent and -independent manner via induction of PUMA. mir-128 13-20 tumor protein p53 Homo sapiens 77-80 23492773-9 2013 Furthermore, miR-128 induces apoptosis in wild (WT) p53 as well as in mutant p53-expressing cells in a p53-dependent and -independent manner via induction of PUMA. mir-128 13-20 tumor protein p53 Homo sapiens 77-80