PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33284947-4 2020 The 5 analyzed proteins involved in lenalidomide"s mode of action were associated with time to progression (TTP); low levels of cereblon and IRF4 protein and high levels of Ikaros, AGO2, and Aiolos were significantly associated with shorter TTP. Lenalidomide 36-48 argonaute RISC catalytic component 2 Homo sapiens 181-185 27142104-6 2016 Upon treatment of IMiD-sensitive MM cells with lenalidomide, the steady-state levels of cereblon were significantly increased, whereas levels of AGO2 were significantly decreased. Lenalidomide 47-59 argonaute RISC catalytic component 2 Homo sapiens 145-149 29788898-13 2019 Lenalidomide decreases expression of protein argonaute-2, which binds to cereblon. Lenalidomide 0-12 argonaute RISC catalytic component 2 Homo sapiens 37-56 30111438-7 2018 Lenalidomide can also play a role in multiple myeloma(MM) cells by modulating miRNA levels and CRBN binding to downstream protein AGO2 expression. Lenalidomide 0-12 argonaute RISC catalytic component 2 Homo sapiens 130-134