PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34680233-6	2021	We have found that lenalidomide-mediated degradation of IKZF1 leads to activation of the G protein-coupled receptor 68 (GPR68)/calcium/calpain pro-apoptotic pathway and inhibition of the regulator of calcineurin 1 (RCAN1)/calcineurin pro-survival pathway in MDS and acute myeloid leukemia (AML).	Lenalidomide	19-31	G protein-coupled receptor 68	Homo sapiens	89-118	
34680233-6	2021	We have found that lenalidomide-mediated degradation of IKZF1 leads to activation of the G protein-coupled receptor 68 (GPR68)/calcium/calpain pro-apoptotic pathway and inhibition of the regulator of calcineurin 1 (RCAN1)/calcineurin pro-survival pathway in MDS and acute myeloid leukemia (AML).	Lenalidomide	19-31	G protein-coupled receptor 68	Homo sapiens	120-125	
27294874-5	2016	In contrast, deletion of GPR68 or inhibition of calcium and calpain activation suppressed LEN-induced cytotoxicity.	Lenalidomide	90-93	G protein-coupled receptor 68	Homo sapiens	25-30	
32437909-1	2020	Our previous study revealed that expression of G protein-coupled receptor 68 (GPR68) was upregulated in MDSL cells, a cell line representing Myelodysplastic Syndromes (MDS), in response to lenalidomide (LEN), and mediated a calcium/calpain proapoptotic pathway.	Lenalidomide	189-201	G protein-coupled receptor 68	Homo sapiens	47-76	
32437909-1	2020	Our previous study revealed that expression of G protein-coupled receptor 68 (GPR68) was upregulated in MDSL cells, a cell line representing Myelodysplastic Syndromes (MDS), in response to lenalidomide (LEN), and mediated a calcium/calpain proapoptotic pathway.	Lenalidomide	189-201	G protein-coupled receptor 68	Homo sapiens	78-83	
32437909-1	2020	Our previous study revealed that expression of G protein-coupled receptor 68 (GPR68) was upregulated in MDSL cells, a cell line representing Myelodysplastic Syndromes (MDS), in response to lenalidomide (LEN), and mediated a calcium/calpain proapoptotic pathway.	Lenalidomide	203-206	G protein-coupled receptor 68	Homo sapiens	47-76	
32437909-1	2020	Our previous study revealed that expression of G protein-coupled receptor 68 (GPR68) was upregulated in MDSL cells, a cell line representing Myelodysplastic Syndromes (MDS), in response to lenalidomide (LEN), and mediated a calcium/calpain proapoptotic pathway.	Lenalidomide	203-206	G protein-coupled receptor 68	Homo sapiens	78-83	
32411498-2	2020	We have previously found that GPR68 induces a proapoptotic pathway in bone marrow (BM) cells from the patients with myelodysplastic syndromes (MDS) after treated with lenalidomide.	Lenalidomide	167-179	G protein-coupled receptor 68	Homo sapiens	30-35	
32984863-5	2020	Depletion of G protein-coupled receptor 68 (GPR68) or an endogenous calcineurin (CaN) inhibitor, regulator of calcineurin 1 (RCAN1), reversed the inhibitory effect of lenalidomide on MDSL cells, an MDS cell line.	Lenalidomide	167-179	G protein-coupled receptor 68	Homo sapiens	13-42	
32984863-5	2020	Depletion of G protein-coupled receptor 68 (GPR68) or an endogenous calcineurin (CaN) inhibitor, regulator of calcineurin 1 (RCAN1), reversed the inhibitory effect of lenalidomide on MDSL cells, an MDS cell line.	Lenalidomide	167-179	G protein-coupled receptor 68	Homo sapiens	44-49	
32984863-6	2020	Intriguingly, both GPR68 and RCAN1 expression levels were upregulated in MDSL cells after treatment with lenalidomide that was dependent on diminishment of IKZF1, indicating that IKZF1 functioned as a transcription repressor for GPR68 and RCAN1.	Lenalidomide	105-117	G protein-coupled receptor 68	Homo sapiens	19-24	
32984863-6	2020	Intriguingly, both GPR68 and RCAN1 expression levels were upregulated in MDSL cells after treatment with lenalidomide that was dependent on diminishment of IKZF1, indicating that IKZF1 functioned as a transcription repressor for GPR68 and RCAN1.	Lenalidomide	105-117	G protein-coupled receptor 68	Homo sapiens	229-234	
32984863-10	2020	Our studies suggest that lenalidomide mediates degradation of IKZF1, leading to derepression of GPR68 and RCAN1 that activates the Ca2+/calpain pro- apoptotic pathway and inhibits the CaN pro-survival pathway, respectively.	Lenalidomide	25-37	G protein-coupled receptor 68	Homo sapiens	96-101