PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33222668-7 2021 At the molecular level, OSI-027 simultaneously blocked mTORC1 and mTORC2 activation, and resulted in the downregulation of phosphor-Akt, phpspho-p70S6k, phosphor-4EBP1, cyclin D1, and cyclin-dependent kinase4 (CDK4). OSI 027 24-31 cyclin dependent kinase 4 Homo sapiens 184-208 33222668-7 2021 At the molecular level, OSI-027 simultaneously blocked mTORC1 and mTORC2 activation, and resulted in the downregulation of phosphor-Akt, phpspho-p70S6k, phosphor-4EBP1, cyclin D1, and cyclin-dependent kinase4 (CDK4). OSI 027 24-31 cyclin dependent kinase 4 Homo sapiens 210-214