PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24704452-0	2014	22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARgamma-LXRalpha-ABCA1 pathway in cholesterosis of the gallbladder.	Pioglitazone	29-41	ATP binding cassette subfamily A member 1	Homo sapiens	112-117	
25280398-0	2015	Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.	Pioglitazone	0-12	ATP binding cassette subfamily A member 1	Homo sapiens	88-93	
25280398-9	2015	In conclusion, we observed that pioglitazone increased ABCA1 expression in an LXR-dependent manner and NCEH1 expression in an LXRalpha-independent manner, which mobilized CE hydrolysis and cholesterol efflux to reduce lipid droplet content in cholesterolosis GBECs.	Pioglitazone	32-44	ATP binding cassette subfamily A member 1	Homo sapiens	55-60	
11712406-8	2001	Recently, it was demonstrated that pioglitazone is also an agonist of PPAR-alpha, which plays a central role in lipid metabolism through enhancing the synthesis of apo AI, apo AII and reverse cholesterol transporters, such as fatty acid transporter molecules, and SR-B1 and ABCA1 reverse cholesterol transport receptors.	Pioglitazone	35-47	ATP binding cassette subfamily A member 1	Homo sapiens	274-279	
24704452-10	2014	The combination of 22(R)-hydroxycholesterol and pioglitazone resulted in a 3.64-fold increase in ABCA1 expression and a high rate of cholesterol efflux.	Pioglitazone	48-60	ATP binding cassette subfamily A member 1	Homo sapiens	97-102	
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	Pioglitazone	125-137	ATP binding cassette subfamily A member 1	Homo sapiens	188-193	
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	Pioglitazone	125-137	ATP binding cassette subfamily A member 1	Homo sapiens	213-218	
21862012-0	2011	Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARgamma/LXRalpha pathway: findings from in vitro and ex vivo studies.	Pioglitazone	0-12	ATP binding cassette subfamily A member 1	Homo sapiens	72-77	
21862012-4	2011	We therefore investigated the effects of pioglitazone on ABCA1/G1 expression in vitro and ex vivo.	Pioglitazone	41-53	ATP binding cassette subfamily A member 1	Homo sapiens	57-62	
21862012-9	2011	RESULTS: Pioglitazone increased LXRalpha/ABCA1/G1 expressions, which enhanced ChE from macrophages.	Pioglitazone	9-21	ATP binding cassette subfamily A member 1	Homo sapiens	41-46	
21862012-10	2011	Inhibition of PPARgamma/LXR pathways revealed that LXR was primarily involved in pioglitazone"s transactivation of ABCA1 but only partially involved for ABCG1.	Pioglitazone	81-93	ATP binding cassette subfamily A member 1	Homo sapiens	115-120	
21862012-12	2011	Sera obtained after pioglitazone treatment promoted ChE and ABCA1/G1 expressions in macrophages.	Pioglitazone	20-32	ATP binding cassette subfamily A member 1	Homo sapiens	60-65	
21862012-13	2011	CONCLUSION: Pioglitazone enhanced ChE from macrophages by increasing ABCA1/G1 in LXR-dependent and -independent manners.	Pioglitazone	12-24	ATP binding cassette subfamily A member 1	Homo sapiens	69-74	
20110608-4	2010	We observed that pioglitazone, but not GW347845, increased cholesterol biosynthetic and lipogenic gene expression after 6 h, and the expression of the cholesterol efflux transporters Abca1 and Abcg1 after 24 h. Co-treatment of pioglitazone with the PPARgamma antagonist GW9662 did not significantly reduce these effects, suggesting a PPARgamma-independent mechanism.	Pioglitazone	17-29	ATP binding cassette subfamily A member 1	Homo sapiens	183-188