PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21396644-11	2011	Telomerase activation by pioglitazone in cultivated cells was prevented by Akt inhibitors.	Pioglitazone	25-37	thymoma viral proto-oncogene 1	Mus musculus	75-78	
30022363-11	2018	Furthermore, the inhibitory effects of PGZ on the activations of ERK and Akt/mTOR signaling, and MMPs were apparently reversed by CCG 63802 administration.	Pioglitazone	39-42	thymoma viral proto-oncogene 1	Mus musculus	73-76	
30022363-12	2018	In conclusion, the protective effect of PGZ on OVA-induced airway inflammation and remodeling might be partly regulated by RGS4 expression through ERK and Akt/mTOR signaling.	Pioglitazone	40-43	thymoma viral proto-oncogene 1	Mus musculus	155-158	
29359338-0	2018	PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone.	Pioglitazone	144-156	thymoma viral proto-oncogene 1	Mus musculus	5-8	
29359338-7	2018	Furthermore, we assessed the influence of anisomycin, a JNK/p38 agonist, and LY294002, a PI3K/AKT inhibitor, on the antidepressant-like effect of pioglitazone in mice.	Pioglitazone	146-158	thymoma viral proto-oncogene 1	Mus musculus	94-97	
29359338-10	2018	Furthermore, at the molecular level, pioglitazone significantly reversed, via PPAR-gamma-dependent increase in neural apoptosis in the PFC of mice, accompanied by upregulation of the PI3K/AKT pathway and down-regulation of the JNK/p38 pathway.	Pioglitazone	37-49	thymoma viral proto-oncogene 1	Mus musculus	188-191	
29359338-12	2018	; In conclusion, our results showed that PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the PFC of mice may be involved in the antidepressant-like effect of pioglitazone.	Pioglitazone	175-187	thymoma viral proto-oncogene 1	Mus musculus	46-49	
29123170-6	2017	By performing image-based drug screening, we found pioglitazone, a PPARgamma agonist, increased the pAkt/Akt ratio, which in turn ameliorated the insulin-induced transcriptional repression of the gluconeogenic gene phosphoenolpyruvate carboxykinase 1.	Pioglitazone	51-63	thymoma viral proto-oncogene 1	Mus musculus	101-104	
21777645-2	2011	Peroxisome proliferator-activated receptor (PPAR) ligands are reported to activate the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, including pioglitazone, which belong to the thiazolidinedione (TZD).	Pioglitazone	147-159	thymoma viral proto-oncogene 1	Mus musculus	124-127	
21360043-0	2011	Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-gamma-independent manner.	Pioglitazone	0-12	thymoma viral proto-oncogene 1	Mus musculus	55-58	
21360043-1	2011	Pioglitazone (PIO), a PPAR-gamma agonist, limits myocardial infarct size by activating Akt and upregulating cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenase (COX)-2.	Pioglitazone	0-12	thymoma viral proto-oncogene 1	Mus musculus	87-90	
21360043-1	2011	Pioglitazone (PIO), a PPAR-gamma agonist, limits myocardial infarct size by activating Akt and upregulating cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenase (COX)-2.	Pioglitazone	14-17	thymoma viral proto-oncogene 1	Mus musculus	87-90	
34082428-6	2021	Moreover, pioglitazone significantly increased beta-arrestin2 signaling in all the examined tissues as estimated from significant increases in phosphatidylinositol 4,5 bisphosphate and phosphorylation of Akt at serine 473 and significant decrease in diacylglycerol level.	Pioglitazone	10-22	thymoma viral proto-oncogene 1	Mus musculus	204-207	
19737384-0	2009	Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.	Pioglitazone	0-12	thymoma viral proto-oncogene 1	Mus musculus	93-96	
19737384-6	2009	CONCLUSION: These data demonstrate that Akt-VEGF pathway is essential for ischemia-induced angiogenic effect of pioglitazone and that pioglitazone exerts this effect via a PPARgamma independent manner.	Pioglitazone	112-124	thymoma viral proto-oncogene 1	Mus musculus	40-43	
17075577-8	2007	PGZ to MCD-fed mice restored the activation of the insulin receptor and of the Akt pathway in response to insulin.	Pioglitazone	0-3	thymoma viral proto-oncogene 1	Mus musculus	79-82	
33577036-0	2021	Effects of PPARgamma agonist pioglitazone on cardiac fibrosis in diabetic mice by regulating PTEN/AKT/FAK pathway.	Pioglitazone	29-41	thymoma viral proto-oncogene 1	Mus musculus	98-101