PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29067321-6	2017	DISCUSSION: Combination therapy with leptin and pioglitazone ameliorates pathologic changes in APP/PS1 mice and may represent a potential treatment approach for AD.	Pioglitazone	48-60	amyloid beta (A4) precursor protein	Mus musculus	95-102	
29275517-6	2018	Elevated Abeta expression and Abeta42 level were found in HG-treated HT-22 cells, accompanied by increased BACE1 protein and mRNA levels as well as enzymatic activity, which was markedly attenuated by three concentrations of Sar and pioglitazone.	Pioglitazone	233-245	amyloid beta (A4) precursor protein	Mus musculus	9-14	
26507867-7	2016	KEY RESULTS: Treatment with PPARgamma agonists, rosiglitazone (0.8 mg kg(-1) ) and pioglitazone (9.0 mg kg(-1) ), for 6 weeks significantly increased Abeta efflux and decreased Abeta influx across the BBB in db/db mice.	Pioglitazone	83-95	amyloid beta (A4) precursor protein	Mus musculus	150-155	
26163517-6	2015	We found that the LXR agonist GW3965 and the PPARgamma agonist pioglitazone were individually able to increase the levels of apoE and related genes, decrease the expression of proinflammatory genes, and facilitate Abeta decreases in the hippocampus.	Pioglitazone	63-75	amyloid beta (A4) precursor protein	Mus musculus	214-219	
23197723-4	2012	The PPARgamma agonist pioglitazone and a novel selective PPARalpha/gamma modulator, DSP-8658, currently in clinical development for the treatment of type 2 diabetes, enhanced the microglial uptake of Abeta in a PPARgamma-dependent manner.	Pioglitazone	22-34	amyloid beta (A4) precursor protein	Mus musculus	200-205	
35431893-6	2022	Surprisingly, Abeta-PET and immunohistochemistry revealed a shift toward higher fibrillary composition of Abeta-plaques during upon chronic pioglitazone treatment.	Pioglitazone	140-152	amyloid beta (A4) precursor protein	Mus musculus	14-19	
35431893-6	2022	Surprisingly, Abeta-PET and immunohistochemistry revealed a shift toward higher fibrillary composition of Abeta-plaques during upon chronic pioglitazone treatment.	Pioglitazone	140-152	amyloid beta (A4) precursor protein	Mus musculus	106-111