PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24867508-0	2014	Effect of pioglitazone on expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in ischemic hindlimb of diabetic rats.	Pioglitazone	10-22	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-71	
27160248-7	2016	Additionally, pioglitazone inhibited HIF-1alpha-dependent angiogenesis by down-regulating the expression of a panel of angiogenic factors.	Pioglitazone	14-26	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	37-47	
24408111-0	2014	Pioglitazone inhibits HIF-1alpha-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells.	Pioglitazone	0-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	22-32	
24408111-2	2014	We hypothesized that pioglitazone would decrease hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent angiogenesis in rat ischemic hindlimb models by altering mitochondrial-derived signals supporting HIF-1alpha activation.	Pioglitazone	21-33	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	49-80	
24408111-2	2014	We hypothesized that pioglitazone would decrease hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent angiogenesis in rat ischemic hindlimb models by altering mitochondrial-derived signals supporting HIF-1alpha activation.	Pioglitazone	21-33	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	82-92	
24408111-2	2014	We hypothesized that pioglitazone would decrease hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent angiogenesis in rat ischemic hindlimb models by altering mitochondrial-derived signals supporting HIF-1alpha activation.	Pioglitazone	21-33	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	202-212	
24408111-5	2014	HIF-1alpha and vascular endothelial growth factor (VEGF) expression in ischemic muscle were also reduced by pioglitazone.	Pioglitazone	108-120	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10	
24408111-6	2014	In vitro, pioglitazone"s effects on both skeletal muscle cells and microvascular endothelial cells were associated with a decrease in autocrine and paracrine angiogenesis measured by matrigel assay, decreased HIF-1alpha expression and activation, as well as increases in both mitochondrial reactive oxygen species and alpha-ketoglutarate, both mitochondria-derived signals which promote HIF-1alpha degradation.	Pioglitazone	10-22	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	209-219	
24408111-6	2014	In vitro, pioglitazone"s effects on both skeletal muscle cells and microvascular endothelial cells were associated with a decrease in autocrine and paracrine angiogenesis measured by matrigel assay, decreased HIF-1alpha expression and activation, as well as increases in both mitochondrial reactive oxygen species and alpha-ketoglutarate, both mitochondria-derived signals which promote HIF-1alpha degradation.	Pioglitazone	10-22	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	387-397	
24408111-7	2014	We conclude that pioglitazone is associated with decreased ischemic limb perfusion and capillary density in relevant rat models of hindlimb ischemia, and these effects are mediated by mitochondria-dependent reductions in HIF-1alpha-dependent angiogenesis.	Pioglitazone	17-29	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	221-231	
24408111-9	2014	Pioglitazone inhibits HIF-1alpha by inhibiting mitochondrial stabilization of HIF-1.	Pioglitazone	0-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	22-32	
24867508-1	2014	OBJECTIVE: To observe effects of the drug pioglitazone on expression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in diabetic rats with hindlimb ischemia, and explore the role of pioglitazone in angiogenesis after ischemia and its possible mechanism.	Pioglitazone	42-54	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	72-103	
24867508-1	2014	OBJECTIVE: To observe effects of the drug pioglitazone on expression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in diabetic rats with hindlimb ischemia, and explore the role of pioglitazone in angiogenesis after ischemia and its possible mechanism.	Pioglitazone	42-54	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	105-115	
24867508-7	2014	The above indicators in pioglitazone-treated diabetic rats were significantly decreased (p < 0.01) with decreased expression of HIF-1alpha and VEGF (p < 0.01), while the microvessel density (MVD) of the ischemic limb was increased (p < 0.01) and blood perfusion was also increased (p < 0.01).	Pioglitazone	24-36	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-141	
24867508-11	2014	It suggested that pioglitazone may improve ischemic limb angiogenesis mechanisms correlated with regulating the HIF-1alpha/VEGF hypoxia response pathway.	Pioglitazone	18-30	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	112-122