PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35189097-8	2022	Furthermore, pioglitazone decreased the density of inducible nitric oxide synthase+ CD68+ macrophages and inhibited the expression of fibrosis-related factors on day 4 after injury.	Pioglitazone	13-25	nitric oxide synthase 2	Rattus norvegicus	51-82	
11468209-4	2001	METHODS AND RESULTS: Pioglitazone (0.1 to 10 micromol/L) significantly enhanced cytokine-induced expression of iNOS and NO production in a dose-dependent manner in rat VSMCs, but 15-deoxy-Delta(12,14)-prostaglandin J2 (up to 10 micromol/L), a native peroxisome proliferator-activated receptor-gamma ligand, showed no effect.	Pioglitazone	21-33	nitric oxide synthase 2	Rattus norvegicus	111-115	
25708949-9	2015	Rats treated with boswellic acids (125 or 250 mg/kg) or pioglitazone showed improved insulin sensitivity and a reduction in liver index, activities of liver enzymes, serum TNF-alpha and IL-6 as well as hepatic iNOS expression and HNE formation compared to HFD group.	Pioglitazone	56-68	nitric oxide synthase 2	Rattus norvegicus	210-214	
24471407-13	2014	Pioglitazone reduced visceral hypersensitivity and defecation frequency, increased nociceptive thresholds, NO production and iNOS activity and shifted stool form towards hard stools in D-IBS rats.	Pioglitazone	0-12	nitric oxide synthase 2	Rattus norvegicus	125-129	
20495845-8	2010	RESULTS: Pioglitazone effectively inhibited NO, iNOS, TNF-alpha, IL-6, IL-1beta production in LPS-stimulated microglial cells.	Pioglitazone	9-21	nitric oxide synthase 2	Rattus norvegicus	48-52	
12871756-4	2003	Pioglitazone reduced the area of gastric ulcers and raised significantly the gastric blood flow at the ulcer margin and downregulated the mRNA for interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS while cyclooxygenase-1 mRNA was not affected.	Pioglitazone	0-12	nitric oxide synthase 2	Rattus norvegicus	198-202	
12871756-6	2003	We conclude that pioglitazone accelerates the healing of preexisting gastric ulcers due to the hyperemia at ulcer margin and the anti-inflammatory action including suppression of interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS and by an overexpression of HSP70.	Pioglitazone	17-29	nitric oxide synthase 2	Rattus norvegicus	230-234	
23563031-11	2013	CONCLUSIONS: Chronic treatment with pioglitazone exerts a more prominent gastroprotective effect on the stomach ulcers of cirrhotic rats compared to control group probably due to constitutive nitric oxide synthase induction or inducible nitric oxide synthase inhibition.	Pioglitazone	36-48	nitric oxide synthase 2	Rattus norvegicus	227-258	
15364003-6	2004	Pioglitazone significantly protected endotoxin-induced overexpression of iNOS in the liver, but not the overproduction of nitric oxide (NO) in plasma.	Pioglitazone	0-12	nitric oxide synthase 2	Rattus norvegicus	73-77