PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17356310-7	2007	Furthermore, myocardial apoptosis was significantly suppressed by acute treatment with pioglitazone as evidenced by the decreased number of TUNEL-positive myocytes and DNA ladder, enhanced Bcl-2 protein expression, reduced Bax and caspase 3 protein expression in a dose-dependent manner compared with vehicle-treated rats.	Pioglitazone	87-99	caspase 3	Rattus norvegicus	231-240	
30127742-8	2018	Pioglitazone also increased AMPK phosphorylation, inhibited p62 and cleaved caspase-3/8 proteins, and activated autophagy-related proteins LC3 II and Beclin-1 in the kidneys of IRI rats.	Pioglitazone	0-12	caspase 3	Rattus norvegicus	76-85	
27175924-5	2016	Exogenous application of pioglitazone, a PPARgamma agonist, reduced the p-Drp1(Ser616) expression, decreased TGI-induced oxidative stress and activated caspase-3 expression, lessened the extents of DNA fragmentation, and diminished the numbers of TUNEL-positive neuronal cells; all of these effects were reversed by GW9662, a PPARgamma antagonist.	Pioglitazone	25-37	caspase 3	Rattus norvegicus	152-161	
26658596-7	2015	RESULTS: Pioglitazone treatment resulted in a decrease in cardiomyocyte apoptosis as revealed by a decrease in cardiac caspase-3, lactate dehydrogenase (LDH) levels and DNA fragmentation, and an increase in Na+K+ATPase levels in diabetic rats.	Pioglitazone	9-21	caspase 3	Rattus norvegicus	119-128	
18470603-16	2008	Compared with the I/R group, the apoptosis rate and positive cell index (PCI) of Bax and Caspase-3 proteins in the pioglitazone group were significantly decreased (P < 0.05), while the PCI of Bcl-2 protein was increased (P < 0.05).	Pioglitazone	115-127	caspase 3	Rattus norvegicus	89-98	
26495791-9	2016	Pioglitazone increased the activity of caspases 3, 8, and 9 in cerulein-activated AR42j cells as well as in the pancreas of rats 3 hours after induction of severe acute pancreatitis.	Pioglitazone	0-12	caspase 3	Rattus norvegicus	39-59	
26398383-9	2015	Pioglitazone exerted an anti-apoptotic effect as reflected by the reduction of the cytosolic cytochrome c and the key downstream executioner caspase-3.	Pioglitazone	0-12	caspase 3	Rattus norvegicus	141-150	
25127682-10	2014	Fenofibrate and pioglitazone also protected against the increased activation of caspase-3, an effector enzyme of the apoptosis cascade that is considered one of the pathological features of PD.	Pioglitazone	16-28	caspase 3	Rattus norvegicus	80-89	
16080818-10	2005	(2) In a dose-dependent manner, the expressions of Bax and Caspase-3 were depressed, while the expression of Bcl-2, PPARgamma protein and PPARgamma mRNA were enhanced by pioglitazone.	Pioglitazone	170-182	caspase 3	Rattus norvegicus	59-68