PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30312763-8	2018	These findings indicate that cigarette smoke induces steroid unresponsiveness in asthmatic airways, and that sulforaphane restores steroid sensitivity via upregulation of Nrf2 and enhancement of HDAC2 expression and activity.	sulforaphane	109-121	histone deacetylase 2	Mus musculus	195-200	
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	histone deacetylase 2	Mus musculus	190-195	
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	histone deacetylase 2	Mus musculus	190-195	
30312763-6	2018	Moreover, the expression and activity of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness, was reduced in mice exposed to cigarette smoke, but restored by sulforaphane treatment.	sulforaphane	179-191	histone deacetylase 2	Mus musculus	41-62	
30312763-6	2018	Moreover, the expression and activity of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness, was reduced in mice exposed to cigarette smoke, but restored by sulforaphane treatment.	sulforaphane	179-191	histone deacetylase 2	Mus musculus	64-69	
29482060-12	2018	Inhibition of HDAC2 activity by sulforaphane was stronger than that by piceatnnaol.	sulforaphane	32-44	histone deacetylase 2	Mus musculus	14-19	
29482060-14	2018	Sulforaphane may also be used as a dietary inhibitor of HDAC2 and class IIa HDAC.	sulforaphane	0-12	histone deacetylase 2	Mus musculus	56-61	
27735126-6	2017	Sulforaphane increased global acetylation of histone 3 (H3) and H4, inhibited HDAC activity, and decreased the level of HDAC2 in primary cortical neurons.	sulforaphane	0-12	histone deacetylase 2	Mus musculus	120-125