PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26985457-2	2015	Anastrozole is subject to direct glucuronidation catalyzed by UDP-glucuronosyltransferase1A4 (UGT1A4).	Anastrozole	0-11	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	62-92	
26985457-2	2015	Anastrozole is subject to direct glucuronidation catalyzed by UDP-glucuronosyltransferase1A4 (UGT1A4).	Anastrozole	0-11	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	94-100	
26985457-3	2015	Interindividual variability in anastrozole glucuronidation may be affected by UGT1A4 SNPs.	Anastrozole	31-42	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	78-84	
25203739-6	2014	This paper reviews the role of genetic polymorphisms of CYP19A1, CYP3A4, and UGT1A4 in the responses of female hormone receptor-positive postmenopausal breast cancer patients to anastrozole.	Anastrozole	178-189	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	77-83	
23371966-6	2013	In this study, we examined individual variability in the glucuronidation of anastrozole and its association with UGT1A4 promoter and coding region polymorphisms.	Anastrozole	76-87	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	113-119	
23371966-0	2013	Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.	Anastrozole	42-53	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	18-24	
24298433-8	2013	UGT1A4 mRNA up regulation was significantly correlated with UGT1A4 protein expression, anastrozole glucuronidation, ERalpha mRNA expression and MRP mRNA expression, but not with ERalpha protein expression.	Anastrozole	87-98	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	0-6	
23371966-8	2013	Anastrozole glucuronidation was correlated (r = 0.99; P < 0.0001) with lamotrigine glucuronidation (a diagnostic substrate for UGT1A4) and with UGT1A4 mRNA expression levels in human liver microsomes (r = 0.99; P < 0.0001).	Anastrozole	0-11	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	130-136	
23371966-8	2013	Anastrozole glucuronidation was correlated (r = 0.99; P < 0.0001) with lamotrigine glucuronidation (a diagnostic substrate for UGT1A4) and with UGT1A4 mRNA expression levels in human liver microsomes (r = 0.99; P < 0.0001).	Anastrozole	0-11	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	147-153	
23371966-9	2013	Recombinant UGT1A4 catalyzed anastrozole glucuronidation, which was inhibited by hecogenin (IC50 = 15 microM), a UGT1A4 specific inhibitor.	Anastrozole	29-40	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	12-18	
23371966-9	2013	Recombinant UGT1A4 catalyzed anastrozole glucuronidation, which was inhibited by hecogenin (IC50 = 15 microM), a UGT1A4 specific inhibitor.	Anastrozole	29-40	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	113-119	
21175441-12	2010	Variable activity of CYP3A4 (and probably UGT1A4), possibly due to genetic polymorphisms and drug interactions, may alter anastrozole disposition and its effects in vivo.	Anastrozole	122-133	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	42-48