PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27637388-8	2016	ROS production, phosphorylated NR1 and NR2B subunits of NMDA receptor were found to be significantly increased in the spinal dorsal horn after intraoperative remifentanil infusion.	Remifentanil	158-170	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	31-34	
28182698-9	2017	Subcutaneously injection of dexmedetomidine at the dose of 50 mug/kg at 30 min before plantar incision significantly attenuated remifentanil-induced mechanical and thermal hyperalgesia from 2 h to 48 h after infusion, and this was associated with reversal of up-regulated NR1 and NR2B subunits in both membrane fraction and total lysate as well as increased PKC and CaMKII expression in spinal cord dorsal horn.	Remifentanil	128-140	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	272-275	
28714352-8	2017	The expressions of NR1, NR2B, p-NR1, and p-NR2B were increased significantly and progressively over time after remifentanil administration, and these increases were all significantly attenuated by either chelerythrine or KN93 but not PD98059.	Remifentanil	111-123	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	19-22	
28714352-8	2017	The expressions of NR1, NR2B, p-NR1, and p-NR2B were increased significantly and progressively over time after remifentanil administration, and these increases were all significantly attenuated by either chelerythrine or KN93 but not PD98059.	Remifentanil	111-123	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	32-35	
25498394-8	2015	RESULTS: We found that membrane trafficking of DOR, NR1 and NR2B subunits in the spinal cord increased after remifentanil administration and surgery.	Remifentanil	109-121	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	52-55	
25867330-0	2015	Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia.	Remifentanil	63-75	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	23-28	
25867330-3	2015	However, the effect of remifentanil on the levels of the GluN1 subunit of the NMDAR in dorsal horn neurons (DHNs) has not been reported.	Remifentanil	23-35	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	57-62	
25867330-4	2015	We investigated the effect of remifentanil, along with ketamine (NMDAR antagonist) and naloxone (mu-opioid receptor antagonist), on GluN1 mRNA levels and the amount of phosphorylated GluN1 in primary cultures of embryonic rat DHNs.	Remifentanil	30-42	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	132-137	
24951883-9	2014	RESULTS: We found that NR1 membrane trafficking in DRG increased, possibly due to GSK-3beta activation after remifentanil infusion.	Remifentanil	109-121	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	23-26	
24147079-8	2013	We found that remifentanil infusion at 1 mug kg(-1) min(-1) and 2 mug kg(-1) min(-1) caused mechanical and thermal hyperalgesia, up-regulated NMDA receptor subunits NR1 and NR2B expression in both membrane fraction and total lysate of the spinal cord dorsal horn and increased GSK-3beta activity in spinal cord dorsal horn.	Remifentanil	14-26	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	165-168	
24147079-9	2013	GSK-3beta inhibitor TDZD-8 significantly attenuated remifentanil-induced mechanical and thermal hyperalgesia from 2 h to 48 h after infusion, and this was associated with reversal of up-regulated NR1 and NR2B subunits in both membrane fraction and total lysate.	Remifentanil	52-64	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	196-199	
23267003-10	2013	More importantly, intraoperative infusion of remifentanil increased NMDA receptor subunits (NR1 and NR2B) trafficking from the intracellular pool to surface pool in the spinal cord, which was significantly attenuated by TDZD-8.	Remifentanil	45-57	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	92-95	
23267003-11	2013	CONCLUSION: The above results suggest that activation of GSK-3beta contributes to remifentanil-induced postoperative hyperalgesia via regulating NMDA receptor subunits (NR1 and NR2B) trafficking in the spinal cord.	Remifentanil	82-94	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	169-172