PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26468894-3	2016	We hypothesized that remifentanil preconditioning confers cardioprotection via the JAK2/STAT3 and/or PI3K/Akt activation-mediated glycogen synthase kinase-3beta inhibition.	Remifentanil	21-33	signal transducer and activator of transcription 3	Rattus norvegicus	88-93	
31583053-0	2019	Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling.	Remifentanil	49-61	signal transducer and activator of transcription 3	Rattus norvegicus	173-178	
26468894-12	2016	Remifentanil preconditioning reduced postischemic myocardial infarction and hemodynamic dysfunction induced by myocardial ischemia reperfusion injury concomitant with increased phosphorylation of STAT3 at tyr-705 (p-STAT3) and glycogen synthase kinase-3beta but not Akt.	Remifentanil	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	196-201	
26468894-12	2016	Remifentanil preconditioning reduced postischemic myocardial infarction and hemodynamic dysfunction induced by myocardial ischemia reperfusion injury concomitant with increased phosphorylation of STAT3 at tyr-705 (p-STAT3) and glycogen synthase kinase-3beta but not Akt.	Remifentanil	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	216-221	
26468894-15	2016	Remifentanil preconditioning also attenuated posthypoxic cardiomyocyte injury and increased p-STAT3 and glycogen synthase kinase-3beta in isolated primary cardiomyocytes and H9C2 cells.	Remifentanil	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	94-99	
26468894-16	2016	STAT3 gene knockdown with specific synthetic RNA cancelled remifentanil preconditioning cardioprotection, whereas glycogen synthase kinase-3beta gene knockdown, which per se did not affect STAT3 under hypoxia/reoxygenation condition, preserved remifentanil preconditioning cardioprotection regardless of STAT3 abrogation.	Remifentanil	59-71	signal transducer and activator of transcription 3	Rattus norvegicus	0-5	
26468894-17	2016	CONCLUSIONS: Remifentanil preconditioning confers cardioprotection primarily via activation of JAK2/STAT3 signaling that can function independent of PI3K/Akt activation.	Remifentanil	13-25	signal transducer and activator of transcription 3	Rattus norvegicus	100-105