PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16287099-8 2006 Inhibition of E6-mediated p53 proteasomal degradation by MG132 resulted in elevated levels of active p53 as demonstrated by p53 small interfering RNA (siRNA) sensitive p21 upregulation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 57-62 H3 histone pseudogene 16 Homo sapiens 168-171 30091530-5 2018 SAHA and MG132 treatment increased the expression levels of ING5, PTEN, p53, Caspase-3, Bax, p21, and p27 but decreased the expression levels of 14-3-3, MMP-2, MMP-9, ADFP, Nanog, c-myc, CyclinD1, CyclinB1, and Cdc25c concentration dependently, similar to ING5. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 9-14 H3 histone pseudogene 16 Homo sapiens 93-96 34002651-8 2021 Our results showed that MG132 downregulated the expression of antiapoptotic proteins, including CDK2, CDK4, Bcl-xL, and Bcl-2, whereas it upregulated the expression of proapoptotic proteins, including p21, p27, p53, p-p53 (ser15, ser20, and ser46), cleaved forms of caspase-3, caspase-7, caspase-9, and PARP, and FOXO3 in U2OS cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 24-29 H3 histone pseudogene 16 Homo sapiens 201-204 33482188-7 2021 MG-132 dose-dependently inhibited the growth of HPFs, induced G2/M phase arrest of cell cycle at a certain dose, and also caused cell apoptosis, with the levels of cleaved caspase3, cleaved PARP, Bax and p21 increased. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 0-6 H3 histone pseudogene 16 Homo sapiens 204-207 17003443-15 2006 The antiproliferative effect of MG132 was significantly reversed in samples transfected with p21 and p27 siRNA, which reduced p21 and p27 protein expression to very low levels that remained below basal control levels, even after treatment with MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 244-249 H3 histone pseudogene 16 Homo sapiens 93-96 23998584-2 2013 Apoptosis of HL-60 cells was detected by flow cytometry, the expression of P21, P27 and P53 proteins in HL-60 cells treated with MG132 was assayed by Western blot. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 129-134 H3 histone pseudogene 16 Homo sapiens 75-78 23998584-7 2013 The expression of P21 and P27 protein increased after treatment of HL-60 cells with MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 84-89 H3 histone pseudogene 16 Homo sapiens 18-21 23998584-10 2013 The P21 and P27 protein may be involved in MG132 induced HL-60 cell apoptosis. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 43-48 H3 histone pseudogene 16 Homo sapiens 4-7 17003443-14 2006 MG132 caused a significant increase in p21 and p27 protein and decrease in CDK2, but no change in p53, p57, CDK4, or CDK6 protein. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 0-5 H3 histone pseudogene 16 Homo sapiens 39-42 17003443-15 2006 The antiproliferative effect of MG132 was significantly reversed in samples transfected with p21 and p27 siRNA, which reduced p21 and p27 protein expression to very low levels that remained below basal control levels, even after treatment with MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 32-37 H3 histone pseudogene 16 Homo sapiens 93-96 17003443-15 2006 The antiproliferative effect of MG132 was significantly reversed in samples transfected with p21 and p27 siRNA, which reduced p21 and p27 protein expression to very low levels that remained below basal control levels, even after treatment with MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 32-37 H3 histone pseudogene 16 Homo sapiens 126-129 24788149-4 2014 We therefore analyzed the L02 cells with MG132 and siRNA treatment for different expression of p21 related to lipid accumulation and lipotoxicity. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 41-46 H3 histone pseudogene 16 Homo sapiens 95-98 22074820-4 2011 The proteasome inhibitors MG132, lactacystin, and proteasome inhibitor I dramatically inhibited cell proliferation and induced apoptosis of PEL cells through the accumulation of p21 and p27. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 26-31 H3 histone pseudogene 16 Homo sapiens 178-181 21864408-9 2011 We treated the cells with proteasome inhibitor MG-132 and found that p21 may be degraded in the proteasome to regulate protein levels. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 47-53 H3 histone pseudogene 16 Homo sapiens 69-72 18064564-6 2008 Induction of the stress related kinases JNK and p38 and the up-regulation of p21 and p27 were also observed after co-treatment of cells with HDACi and MG-132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 151-157 H3 histone pseudogene 16 Homo sapiens 77-80 17224908-6 2007 Proteasome inhibition by MG132 increases the occupancy of p53 protein at p53-responsive p21(waf1) promoter. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 25-30 H3 histone pseudogene 16 Homo sapiens 88-91 15147952-4 2004 Using the proteasome-specific inhibitors, MG132 and lactacystin, we show that the p53, the cdk inhibitors p21 and p27, and cyclin A are degraded by the ubiquitin-proteasome pathway in human osteosarcoma cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 42-47 H3 histone pseudogene 16 Homo sapiens 106-109 15122333-3 2004 Inhibition of the proteasome complex with MG-132 increased p21 protein levels in TGCT cells but much more in A2780 cells, whereas cisplatin had no additional effect on p21 protein levels. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 42-48 H3 histone pseudogene 16 Homo sapiens 59-62 16513842-9 2006 The protease/proteasome inhibitor MG132 protected AR and p21 from the effects of trichostatin A and doxorubicin and inhibited trichostatin A-induced cell death in AR-positive prostate cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 34-39 H3 histone pseudogene 16 Homo sapiens 57-60 12610816-10 2003 The expression of the p53 response proteins, MDM2 and p21, was elevated in MG132 treated chondrocytes. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 75-80 H3 histone pseudogene 16 Homo sapiens 54-57 10837373-8 2000 With the addition of MG-132, a proteasome inhibitor, to B[a]P or 1-NP treatments, both p21 and p53 protein levels were increased; however, the increase in p21 protein levels was significantly larger than the increase in p53 protein levels. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 21-27 H3 histone pseudogene 16 Homo sapiens 87-90 10837373-8 2000 With the addition of MG-132, a proteasome inhibitor, to B[a]P or 1-NP treatments, both p21 and p53 protein levels were increased; however, the increase in p21 protein levels was significantly larger than the increase in p53 protein levels. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 21-27 H3 histone pseudogene 16 Homo sapiens 155-158 9438391-2 1998 Using the proteasome-specific inhibitors, MG132 (N-acetyl-L-leucinyl-L-leucinal-L-leucinal) and lactacystin, here we show that the p53-response proteins, bax and mdm2 as well as p21, are degraded by the ubiquitin-proteasome pathway in HeLa cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 42-47 H3 histone pseudogene 16 Homo sapiens 178-181