PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25548100-9	2015	Carfilzomib-induced Noxa and Bik sequestered Mcl-1 and ABT-263 released Bik and Bak from Bcl-xL, suggesting a mechanism for drug synergy.	carfilzomib	0-11	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	20-24	
27026200-8	2016	Carfilzomib also induced accumulation of MCL-1 and Noxa, whereby MCL-1 preferentially formed a complex with Noxa and consequently relieved MCL-1"s protective effect on sequestering Bak.	carfilzomib	0-11	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	51-55	
27026200-8	2016	Carfilzomib also induced accumulation of MCL-1 and Noxa, whereby MCL-1 preferentially formed a complex with Noxa and consequently relieved MCL-1"s protective effect on sequestering Bak.	carfilzomib	0-11	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	108-112	
27026200-9	2016	Accordingly, depletion of Noxa or both Bak and Bax conferred protection against carfilzomib-induced cell death.	carfilzomib	80-91	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	26-30	
27246906-8	2016	We found that carfilzomib increases NOXA mRNA expression, as expected, and TG02 treatment caused a decrease in Mcl-1 protein but not mRNA levels.	carfilzomib	14-25	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	36-40	
27246906-11	2016	Taken together our data suggest that dual inhibition of Mcl-1 via decreased expression and the induction of its antagonist NOXA by the combination of carfilzomib and TG02 is active in myeloma and warrants further testing preclinically and in clinical trials.	carfilzomib	150-161	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	123-127	
25548100-2	2015	To overcome KRAS-mediated apoptosis resistance, the irreversible proteasome inhibitor, carfilzomib, was evaluated and found to potently induce Noxa, which was dependent upon c-Myc, and Bik.	carfilzomib	87-98	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	143-147	
25548100-7	2015	Concurrent Bcl-xL antagonism by the BH3 mimetic ABT-263 combined with carfilzomib synergistically enhanced apoptosis that was dependent on Bax or p53, and was attenuated by Noxa or Bik shRNA.	carfilzomib	70-81	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	173-177	
25548100-11	2015	Furthermore, antagonizing Bcl-xL enabled carfilzomib-induced Noxa and Bik to induce synergistic apoptosis that reversed KRAS-mediated resistance.	carfilzomib	41-52	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	61-65	
22411899-6	2012	Genetic interruption of c-jun-NH(2)-kinase (JNK) and Noxa by short hairpin RNA knockdown, ectopic Mcl-1 expression, or enforced activation of AKT significantly attenuated carfilzomib/obatoclax-mediated apoptosis.	carfilzomib	171-182	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	53-57