PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22749133-0	2013	The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.	diosmetin	15-24	mitogen-activated protein kinase 1	Homo sapiens	159-162	
18269307-0	2008	Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway.	diosmetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	82-85	
18269307-0	2008	Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway.	diosmetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	90-129	
18269307-8	2008	Induction of differentiation by diosmetin was associated with increased PKCdelta phosphorylation and the activations of Rac1 and p38 and ERK1/2 kinases.	diosmetin	32-41	mitogen-activated protein kinase 1	Homo sapiens	129-132	
18269307-10	2008	In addition, blocking p38 and ERK1/2 by siRNA transfection also suppressed diosmetin-induced cell differentiation.	diosmetin	75-84	mitogen-activated protein kinase 1	Homo sapiens	22-25	
18269307-11	2008	CONCLUSIONS: In this study, we show that diosmetin induced osteoblastic differentiation through the PKCdelta-Rac1-MEK3/6-p38 and PKCdelta-Rac1-MEK1/2- ERK1/2-Runx2 pathways and that it is a promising agent for treating osteoporosis.	diosmetin	41-50	mitogen-activated protein kinase 1	Homo sapiens	121-124