PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34086130-0 2021 Correction to: Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway. diosmetin 15-24 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 33811596-0 2021 Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway. diosmetin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 33811596-6 2021 Mechanistically, our results revealed that Dio inhibited Nrf2 and induced the production of reactive oxygen species (ROS). diosmetin 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 33811596-8 2021 Additionally, overexpression of Nrf2 partially suppressed the Dio-induced apoptosis and proliferation inhibition in these cells. diosmetin 62-65 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 33811596-9 2021 These findings indicate that Dio exerts an anti-tumor activity by upregulating ROS levels and inhibiting Nrf2, indicating that Dio is a promising chemotherapeutic candidate for the treatment of ovarian cancer. diosmetin 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 33811596-9 2021 These findings indicate that Dio exerts an anti-tumor activity by upregulating ROS levels and inhibiting Nrf2, indicating that Dio is a promising chemotherapeutic candidate for the treatment of ovarian cancer. diosmetin 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 29568961-0 2018 Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway. diosmetin 26-35 NFE2 like bZIP transcription factor 2 Homo sapiens 118-122 29568961-10 2018 Furthermore, pretreatment with diosmetin elevated mRNA and protein expression levels of Nrf2, HO-1 and NQO1. diosmetin 31-40 NFE2 like bZIP transcription factor 2 Homo sapiens 88-92 29568961-11 2018 The present study is the first, to the best of our knowledge, to demonstrate that activation of the Nrf2/NQO1-HO-1 signaling pathway maybe involved in the cytoprotective effects of diosmetin against oxidative stress. diosmetin 181-190 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104