PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15334063-2 2004 In this study, we found that pretreatment with luteolin, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells. Luteolin 47-55 tumor necrosis factor Homo sapiens 95-103 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. Luteolin 40-48 tumor necrosis factor Homo sapiens 246-249 35372072-15 2022 Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway. Luteolin 0-8 tumor necrosis factor Homo sapiens 227-230 32117796-7 2020 Linarin, sinensetin, cedar acid, isoliquiritigenin, sinigrin, luteolin, chlorogenic acid, orientin, epigoitrin, and rupestonic acid exhibited significant effects on TNF-alpha expression, which is almost consistent with predicted results. Luteolin 62-70 tumor necrosis factor Homo sapiens 165-174 32489059-7 2020 Molecular docking prediction showed that luteolin, quercetin and catalpol had a strong binding activity with Akt1; luteolin had strong binding activity but quercetin and catalpol had a certain binding activity with TNFalpha. Luteolin 41-49 tumor necrosis factor Homo sapiens 215-223 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Luteolin 144-152 tumor necrosis factor Homo sapiens 27-30 32017949-13 2020 Moreover, luteolin and kaempferol, the main activity compounds in MHF, significantly inhibited TNF-alpha-induced HPMVEC apoptosis, and downregulated NF-kappaB/MLCK pathway by targeting NOX4. Luteolin 10-18 tumor necrosis factor Homo sapiens 95-104 31665675-0 2019 Combination of curcumin and luteolin synergistically inhibits TNF-alpha-induced vascular inflammation in human vascular cells and mice. Luteolin 28-36 tumor necrosis factor Homo sapiens 62-71 31665675-3 2019 The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-alpha)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium. Luteolin 81-89 tumor necrosis factor Homo sapiens 114-141 31665675-5 2019 We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect. Luteolin 247-255 tumor necrosis factor Homo sapiens 19-28 31665675-3 2019 The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-alpha)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium. Luteolin 81-89 tumor necrosis factor Homo sapiens 143-152 31665675-7 2019 Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus. Luteolin 33-41 tumor necrosis factor Homo sapiens 99-108 31665675-4 2019 Our results show that combined curcumin (1 muM) and luteolin (0.5 muM) synergistically (combination index is 0.60) inhibited TNF-alpha-induced monocytes adhesion to human EA.hy926 endothelial cells while the individual chemicals did not have such effect at the selected concentrations. Luteolin 52-60 tumor necrosis factor Homo sapiens 125-134 18972039-1 2008 Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-alpha-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-alpha-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy. Luteolin 47-55 tumor necrosis factor Homo sapiens 70-79 24146961-0 2013 Digitoflavone inhibits IkappaBalpha kinase and enhances apoptosis induced by TNFalpha through downregulation of expression of nuclear factor kappaB-regulated gene products in human pancreatic cancer cells. Luteolin 0-13 tumor necrosis factor Homo sapiens 77-85 24146961-3 2013 We found that pretreatment with digitoflavone, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in several human pancreatic cancer cells. Luteolin 32-45 tumor necrosis factor Homo sapiens 85-93 24146961-4 2013 In search of the molecular basis of the sensitization effect of digitoflavone, digitoflavone was found to inhibit TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB) which is the main survival factor in TNFalpha signaling. Luteolin 64-77 tumor necrosis factor Homo sapiens 114-122 24146961-4 2013 In search of the molecular basis of the sensitization effect of digitoflavone, digitoflavone was found to inhibit TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB) which is the main survival factor in TNFalpha signaling. Luteolin 64-77 tumor necrosis factor Homo sapiens 231-239 24146961-4 2013 In search of the molecular basis of the sensitization effect of digitoflavone, digitoflavone was found to inhibit TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB) which is the main survival factor in TNFalpha signaling. Luteolin 79-92 tumor necrosis factor Homo sapiens 114-122 24146961-4 2013 In search of the molecular basis of the sensitization effect of digitoflavone, digitoflavone was found to inhibit TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB) which is the main survival factor in TNFalpha signaling. Luteolin 79-92 tumor necrosis factor Homo sapiens 231-239 19739098-3 2009 Based on our previous observations that the nutrient flavonoid luteolin potently blocks TNF-induced NF-kappaB activation in cancer cells, we investigated if the combination of SMC3 and luteolin would achieve a synergistic anticancer activity. Luteolin 63-71 tumor necrosis factor Homo sapiens 88-91 28939905-8 2017 Co-ultramicronized palmitoylethanolamide/luteolin, an established anti-inflammatory/ neuroprotective agent, reduced Saa1 expression in OPCs subjected to TNF-alpha treatment. Luteolin 41-49 tumor necrosis factor Homo sapiens 153-162 26569039-4 2016 Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-alpha-induced NF-kappaB reporter gene expression on HeLa cells up to 30 and 100 muM. Luteolin 44-52 tumor necrosis factor Homo sapiens 68-77 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Luteolin 63-71 tumor necrosis factor Homo sapiens 222-231 17296806-3 2007 Luteolin, a naturally occurring polyphenol flavonoid, has been reported to sensitize colorectal cancer cells to TNF-induced apoptosis through suppression of NF-kappaB; however, the mechanisms of this effect have not been well elucidated. Luteolin 0-8 tumor necrosis factor Homo sapiens 112-115