PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17384531-6 2007 Analyses of structure-activity relationships of 45 flavones, flavonols and their related compounds showed that luteolin, ayanin, apigenin and fisetin were the strongest inhibitors of IL-4 production with an IC(50) value of 2-5 microM and determined a fundamental structure for the inhibitory activity. Luteolin 111-119 interleukin 4 Mus musculus 183-187 31976547-10 2020 Moreover, luteolin treatment mitigated irinotecan-induced oxidative stress (i.e. by reducing the levels of ROS and LOOH, and augmenting endogenous antioxidants) and inflammation (i.e. through the decrease of MPO enzyme activity, TNF, IL-1beta, and IL-6 levels; and increasing IL-4 and IL-10). Luteolin 10-18 interleukin 4 Mus musculus 276-280