PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34595237-7 2021 The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide). Luteolin 214-222 thymoma viral proto-oncogene 1 Mus musculus 45-48 34671661-10 2021 Taken together, our study showed that the traditional Chinese medicine QJC, quercetin, luteolin, kaempferol, scutellarein, and stigmasterol alleviated the pathological condition of small intestine tissue and relieved stress-induced diarrhea by increasing the expression levels of PI3K and Akt and inhibiting the expression levels of PTEN. Luteolin 87-95 thymoma viral proto-oncogene 1 Mus musculus 289-292 34595237-7 2021 The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide). Luteolin 214-222 thymoma viral proto-oncogene 1 Mus musculus 383-386 34595237-7 2021 The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide). Luteolin 309-317 thymoma viral proto-oncogene 1 Mus musculus 45-48 34595237-7 2021 The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide). Luteolin 309-317 thymoma viral proto-oncogene 1 Mus musculus 383-386 22843013-8 2013 Quercetin, luteolin, and EGCG inhibited inflammation-evoked IKKbeta activation and IRS-1 serine phosphorylation in adipose tissue, and thereby effectively restored glucose load-stimulated IRS-1 tyrosine and Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in adipocytes. Luteolin 11-19 thymoma viral proto-oncogene 1 Mus musculus 207-210 22843013-5 2013 Luteolin and EGCG, but not quercetin, inhibited glucose load-induced insulin receptor substrate-1(IRS-1) tyrosine and Akt phosphorylation in adipose tissue. Luteolin 0-8 thymoma viral proto-oncogene 1 Mus musculus 118-121 21513709-5 2011 Luteolin and chicoric acid co-treatment inhibited phosphorylation of NF-kappaB and Akt, but had no effect on extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38. Luteolin 0-8 thymoma viral proto-oncogene 1 Mus musculus 83-86 21513709-0 2011 Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-kappaB translocation in LPS stimulated RAW 264.7 cells. Luteolin 0-8 thymoma viral proto-oncogene 1 Mus musculus 101-104